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TBK1 抗体 (pSer172)

TBK1 适用: 人, 小鼠 WB 宿主: 小鼠 Monoclonal J133-1171 unconjugated
产品编号 ABIN967614
发货至: 中国
  • 抗原 See all TBK1 抗体
    TBK1 (TANK-Binding Kinase 1 (TBK1))
    抗原表位
    • 9
    • 8
    • 8
    • 7
    • 6
    • 6
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer172
    适用
    • 71
    • 49
    • 28
    • 6
    • 6
    • 6
    • 6
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    人, 小鼠
    宿主
    • 74
    • 11
    • 1
    小鼠
    克隆类型
    • 71
    • 15
    单克隆
    标记
    • 46
    • 8
    • 8
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This TBK1 antibody is un-conjugated
    应用范围
    • 59
    • 42
    • 25
    • 11
    • 8
    • 7
    • 4
    • 2
    • 2
    • 1
    Western Blotting (WB)
    品牌
    BD Pharmingen™
    交叉反应 (详细)
    Predicted: Mouse
    产品特性
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    免疫原
    Phosphorylated Human TBK1
    克隆位点
    J133-1171
    亚型
    IgG2b kappa
    Top Product
    Discover our top product TBK1 Primary Antibody
  • 限制
    仅限研究用
  • 状态
    Liquid
    浓度
    0.5 mg/mL
    缓冲液
    Aqueous buffered solution containing ≤0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Store undiluted at 4°C.
  • Viatour, Merville, Bours, Chariot: "Phosphorylation of NF-kappaB and IkappaB proteins: implications in cancer and inflammation." in: Trends in biochemical sciences, Vol. 30, Issue 1, pp. 43-52, (2005) (PubMed).

    Kishore, Huynh, Mathialagan, Hall, Rouw, Creely, Lange, Caroll, Reitz, Donnelly, Boddupalli, Combs, Kretzmer, Tripp: "IKK-i and TBK-1 are enzymatically distinct from the homologous enzyme IKK-2: comparative analysis of recombinant human IKK-i, TBK-1, and IKK-2." in: The Journal of biological chemistry, Vol. 277, Issue 16, pp. 13840-7, (2002) (PubMed).

  • 抗原
    TBK1 (TANK-Binding Kinase 1 (TBK1))
    别名
    TBK1 (TBK1 产品)
    别名
    nak antibody, t2k antibody, TBK1 antibody, wu:fk70c05 antibody, zgc:136548 antibody, NAK antibody, T2K antibody, 1200008B05Rik antibody, AI462036 antibody, AW048562 antibody, TANK binding kinase 1 L homeolog antibody, TANK binding kinase 1 antibody, TANK-binding kinase 1 antibody, tbk1.L antibody, TBK1 antibody, tbk1 antibody, Tbk1 antibody
    背景
    NF-kB is a ubiquitously expressed transcription factor that regulates many cytokine and Ig genes. It is involved in immune, inflammatory, viral, and acute phase responses. In most cells, NF-kB is sequestered in an inactive cytoplasmic form via interactions with the inhibitory proteins IkBalpha, IkBbeta, and IkBepsilon. Stimulation induces the release, activation, and nuclear translocation of NF-kB. Release of NF-kB results from the phosphorylation and proteolytic degradation of the IkB proteins. Two cytokine-inducible IkappaB kinases (IKKa and IKKb) phosphorylate and target the IkB proteins for degradation via the ubiquitin pathway. IKKg/NEMO, a third member of the IKK complex, functions as a regulatory subunit and interacts directly with IKKb. TBK1 (TANK-binding kinase 1, also known as T2K or NAK), a protein of 729 amino acids, is another member of the IKK family of kinases regulating NF-kB downstream of the tumor necrosis factor and Toll-like receptor pathways. TBK1 forms a complex with the adaptor proteins TANK (TRAF-associated NF-kB activator) and TRAF2 (TNF-receptor-associated factor 2), and this oligomer is required for activation and phosphorylation of TBK1 at serine 172 (S172).
    The J133-1171 monoclonal antibody recognizes the phosphorylated S172 of human TBK1.
    Synonyms: T2K, NAK
    分子量
    80 kDa
    途径
    TLR signaling, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, SARS-CoV-2 Protein Interactome
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