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SNCA 抗体 (pTyr125, Tyr125)

Name: SNCA 抗体 (pTyr125, Tyr125)
SKU: ABIN967584
Availability: OutOfStock

SNCA 适用: 人 WB 宿主: 小鼠 Monoclonal I57-628 unconjugated

Western blot analysis of alpha-Synuclein (pY125).

1 image

(5 references)

产品编号 ABIN967584

发货至: 中国

Datasheet as PDF

抗原 See all SNCA 抗体

SNCA (Synuclein, alpha (SNCA))
抗原表位
73

32

28

23

16

15

13

11

11

5

4

4

4

4

4

4

3

3

3

3

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
pTyr125, Tyr125
适用
307

207

207

14

10

10

9

7

7

5

2

2

1

1

1

1
人
宿主
248

101

6

1

1

1
小鼠
Compatible Secondaries
克隆类型
232

127
单克隆
标记
158

25

22

17

11

9

9

9

9

9

9

8

8

7

7

7

6

6

6

6

6

5
This SNCA antibody is un-conjugated
应用范围
250

171

111

83

80

74

68

54

49

49

23

21

13

9

7

2

2

2

1

1

1
Western Blotting (WB)

品牌

BD Pharmingen™

产品特性

1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3. Please refer to us for technical protocols.

纯化方法

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

免疫原

Phosphorylated peptide corresponding to the region including the Tyrosine 125 residue of alpha-Synuclein

克隆位点

I57-628

亚型

IgG2b kappa

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anti-Synuclein, alpha (SNCA) (AA 40-140), (pSer129) antibody (Atto 488)
SNCA 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal Atto 488

anti-Synuclein, alpha (SNCA) (AA 40-140), (pSer129) antibody (Atto 390)
SNCA 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal Atto 390

anti-Synuclein, alpha (SNCA) (AA 124-134), (pSer129) antibody
SNCA 适用: 人 WB, ELISA, IHC, ICC 宿主: 兔 Monoclonal J18 unconjugated

anti-Synuclein, alpha (SNCA) (AA 124-134), (pSer129) antibody (HRP)
SNCA 适用: 人 WB, ELISA, IHC, ICC 宿主: 兔 Monoclonal J18 HRP

anti-Synuclein, alpha (SNCA) (AA 124-134), (pSer129) antibody (FITC)
SNCA 适用: 人 WB, ELISA, IHC, ICC 宿主: 兔 Monoclonal J18 FITC

anti-Synuclein, alpha (SNCA) (AA 124-134), (pSer129) antibody (PE)
SNCA 适用: 人 WB, ELISA, IHC, ICC 宿主: 兔 Monoclonal J18 PE

anti-Synuclein, alpha (SNCA) (AA 61-140) antibody
SNCA 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-Synuclein, alpha (SNCA) (AA 40-140), (pSer129) antibody
SNCA 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Synuclein, alpha (SNCA) (AA 40-140), (pSer129) antibody (HRP)
SNCA 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal HRP

说明

Related Products: ABIN967389

限制

仅限研究用
状态

Liquid

浓度

0.5 mg/mL

缓冲液

Aqueous buffered solution containing ≤0.09 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C

储存方法

Store undiluted at 4°C.
Forman, Trojanowski, Lee: "Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs." in: Nature medicine, Vol. 10, Issue 10, pp. 1055-63, (2004) (PubMed).

Nakamura, Yamashita, Nagano, Takahashi, Avraham, Avraham, Matsumoto, Nakamura: "Activation of Pyk2/RAFTK induces tyrosine phosphorylation of alpha-synuclein via Src-family kinases." in: FEBS letters, Vol. 521, Issue 1-3, pp. 190-4, (2002) (PubMed).

Takahashi, Yamashita, Nakamura, Nagano, Nakamura: "Tyrosine 125 of alpha-synuclein plays a critical role for dimerization following nitrative stress." in: Brain research, Vol. 938, Issue 1-2, pp. 73-80, (2002) (PubMed).

Ellis, Schwartzberg, Grider, Fink, Nussbaum: "alpha-synuclein is phosphorylated by members of the Src family of protein-tyrosine kinases." in: The Journal of biological chemistry, Vol. 276, Issue 6, pp. 3879-84, (2001) (PubMed).

Nakamura, Yamashita, Takahashi, Nakamura: "Activated Fyn phosphorylates alpha-synuclein at tyrosine residue 125." in: Biochemical and biophysical research communications, Vol. 280, Issue 4, pp. 1085-92, (2001) (PubMed).
抗原

SNCA (Synuclein, alpha (SNCA))

别名

alpha Synuclein (SNCA 产品)

别名

snca antibody, MGC64356 antibody, LOC619283 antibody, NACP antibody, alphaSYN antibody, PARK1 antibody, PARK4 antibody, PD1 antibody, synuclein alpha L homeolog antibody, alpha-synuclein antibody, synuclein alpha antibody, synuclein, alpha antibody, snca.L antibody, LOC619283 antibody, SNCA antibody, Snca antibody

背景

The 140-amino-acid alpha-Synuclein protein is identical to the non-amyloid-beta component precursor (NACP), a presynaptic protein involved in amyloidogenesis in Alzheimer's disease (AD). This protein is expressed in brain, primarily in presynaptic nerve terminals. Although the exact function of the Synucleins has not been determined, they have been linked to the prominent neurodegenerative disorders AD and Parkinson's disease. The Tyrosine 125 (Y125) residue of alpha-Synuclein plays an important role in stress-induced dimerization of the protein and is phosphorylated by Pyk/RAFTK via the Src-family kinases Fyn and c-Src.
The I57-628 antibody recognizes alpha-Synuclein phosphorylated at Y125.

分子量

19 kDa

途径

Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity