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P-Glycoprotein 抗体

适用: 人 WB, FACS, IP 宿主: 小鼠 Monoclonal 17F9 unconjugated
产品编号 ABIN967562
发货至: 中国
  • 抗原 See all P-Glycoprotein products
    P-Glycoprotein
    适用
    • 25
    • 10
    • 9
    • 2
    宿主
    • 21
    • 5
    小鼠
    克隆类型
    • 13
    • 12
    • 1
    单克隆
    标记
    • 14
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This P-Glycoprotein antibody is un-conjugated
    应用范围
    • 15
    • 7
    • 6
    • 4
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP)
    品牌
    BD Pharmingen™
    产品特性
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    克隆位点
    17F9
    亚型
    IgG2b
  • 应用备注
    Positive control cells are available through special order
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    0.5 mg/mL
    缓冲液
    Aqueous buffered solution containing ≤0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Store undiluted at 4°C.
  • Shi, Wrin, Reeder, Liu, Ring: "High-affinity monoclonal antibodies against P-glycoprotein." in: Clinical immunology and immunopathology, Vol. 76, Issue 1 Pt 1, pp. 44-51, (1995) (PubMed).

    Bénard, Bourhis, Riou: "Clinical significance of multiple drug resistance in human cancers." in: Anticancer research, Vol. 10, Issue 5A, pp. 1297-302, (1990) (PubMed).

    Goldstein, Galski, Fojo, Willingham, Lai, Gazdar, Pirker, Green, Crist, Brodeur: "Expression of a multidrug resistance gene in human cancers." in: Journal of the National Cancer Institute, Vol. 81, Issue 2, pp. 116-24, (1989) (PubMed).

  • 抗原
    P-Glycoprotein
    Abstract
    P-Glycoprotein 产品
    别名
    ABC20 antibody, CD243 antibody, CLCS antibody, GP170 antibody, MDR1 antibody, P-GP antibody, PGY1 antibody, Abcb1 antibody, Mdr1a antibody, ABCB1 antibody, ABCB4 antibody, CMDR1 antibody, xemdr antibody, ATP binding cassette subfamily B member 1 antibody, ATP binding cassette subfamily B member 1A antibody, ATP binding cassette subfamily B member 1 L homeolog antibody, ABCB1 antibody, Abcb1a antibody, abcb1.L antibody
    背景
    Reacts with a 170-180 kDa transmembrane glycoprotein (P-glycoprotein), a product of the multidrug resistance-1 (MDR1) gene. This glycoprotein is expressed on MDR positive cells and has been reported to be expressed on many normal tissues, such as adrenal glands and endothelium, in the brain and skin. P-glycoprotein is known to impart drug resistance to cells by pumping many anti-cancer drugs out of the cytoplasm. 17F9 antibody binds to the surface of the viable, unfixed MDR+ cell line, PMG-Y (please inquire), and is able to partially block the binding of UIC2 antibody (another MDR-specific monoclonal antibody). Immunoprecipitation application is reported, but not routinely tested in house.
    Synonyms: MDR
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