MADCAM1 抗体
(9 references)-
- 抗原 See all MADCAM1 抗体
- MADCAM1 (Mucosal Vascular Addressin Cell Adhesion Molecule 1 (MADCAM1))
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适用
- 小鼠
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宿主
- 大鼠
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克隆类型
- 单克隆
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标记
- This MADCAM1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoaffinity Chromatography (IAC), Blocking Reagent (BR)
- 品牌
- BD Pharmingen™
- 产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Mouse endothelial cells from BALB/c mouse mesenteric and peripheral lymph nodes.
- 克隆位点
- MECA-367
- 亚型
- IgG2a kappa
- Top Product
- Discover our top product MADCAM1 Primary Antibody
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anti-Mucosal Vascular Addressin Cell Adhesion Molecule 1 (MADCAM1) antibody
MADCAM1 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Mucosal Vascular Addressin Cell Adhesion Molecule 1 (MADCAM1) antibodyMADCAM1 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Mucosal Vascular Addressin Cell Adhesion Molecule 1 (MADCAM1) (AA 173-190), (Middle Region) antibodyMADCAM1 适用: 人 WB, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Mucosal Vascular Addressin Cell Adhesion Molecule 1 (MADCAM1) (AA 151-250) antibodyMADCAM1 适用: 人, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Mucosal Vascular Addressin Cell Adhesion Molecule 1 (MADCAM1) (AA 19-317) antibodyMADCAM1 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Mucosal Vascular Addressin Cell Adhesion Molecule 1 (MADCAM1) (AA 85-180) antibodyMADCAM1 适用: 小鼠 WB, FACS, ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Mucosal Vascular Addressin Cell Adhesion Molecule 1 (MADCAM1) (AA 29-297) antibodyMADCAM1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Mucosal Vascular Addressin Cell Adhesion Molecule 1 (MADCAM1) (AA 235-284) antibodyMADCAM1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Mucosal Vascular Addressin Cell Adhesion Molecule 1 (MADCAM1) antibodyMADCAM1 适用: 人 WB, FACS, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 314G8 unconjugated
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- 应用备注
- For IHC, we recommend the use of purified MECA-367 mAb in our special formulation for immunohistochemistry.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.5 mg/mL
- 缓冲液
- Aqueous buffered solution containing ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Store undiluted at 4°C.
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: "Involvement of beta 7 integrin and mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in the development of diabetes in obese diabetic mice." in: Diabetes, Vol. 46, Issue 10, pp. 1542-7, (1997) (PubMed).
: "Recirculation and homing of lymphocyte subsets: dual homing specificity of beta 7-integrin(high)-lymphocytes in nonobese diabetic mice." in: Blood, Vol. 88, Issue 3, pp. 934-44, (1996) (PubMed).
: "Expression of the mucosal vascular addressin, MAdCAM-1, on sinus-lining cells in the spleen." in: The American journal of pathology, Vol. 147, Issue 3, pp. 763-71, (1995) (PubMed).
: "L-selectin-mediated lymphocyte rolling on MAdCAM-1." in: Nature, Vol. 366, Issue 6456, pp. 695-8, (1994) (PubMed).
: "Role of alpha 4-integrins in lymphocyte homing to mucosal tissues in vivo." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 152, Issue 7, pp. 3282-93, (1994) (PubMed).
: "Induction of vascular addressins and adhesion molecules in the pancreas of IFN-gamma transgenic mice." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 152, Issue 9, pp. 4597-603, (1994) (PubMed).
: "Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1." in: Cell, Vol. 74, Issue 1, pp. 185-95, (1993) (PubMed).
: "MAdCAM-1 has homology to immunoglobulin and mucin-like adhesion receptors and to IgA1." in: Nature, Vol. 363, Issue 6428, pp. 461-4, (1993) (PubMed).
: "A tissue-specific endothelial cell molecule involved in lymphocyte homing." in: Nature, Vol. 331, Issue 6151, pp. 41-6, (1988) (PubMed).
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: "Involvement of beta 7 integrin and mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in the development of diabetes in obese diabetic mice." in: Diabetes, Vol. 46, Issue 10, pp. 1542-7, (1997) (PubMed).
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- 抗原
- MADCAM1 (Mucosal Vascular Addressin Cell Adhesion Molecule 1 (MADCAM1))
- 别名
- MAdCAM-1 (MADCAM1 产品)
- 别名
- MACAM1 antibody, AV211525 antibody, mucosal vascular addressin cell adhesion molecule 1 antibody, MADCAM1 antibody, Madcam1 antibody
- 背景
- The MECA-367 antibody reacts with mucosal vascular addressin MAdCAM-1. In the fetus and neonate, MAdCAM-1 is the predominant vascular addressin on the high endothelial venules (HEV) of peripheral lymph nodes. In adult mice, MAdCAM-1 is preferentially expressed in mucosal lymphoid tissues and lamina propria, it is also expressed on sinus-lining cells in the spleen. MAdCAM-1 expression is upregulated on the HEV of peripheral lymph nodes in adult NOD mice4 and is involved in the development of diabetes and insulitis. Furthermore, there is evidence that IFN-gamma can induce MAdCAM-1 expression in non-mucosal sites in adult mice. MAdCAM-1 is a predominant ligand for integrin alpha4beta7, a lymphocyte mucosal homing receptor, and a facultative ligand for CD62L (L-selectin). MECA-367 mAb binds to the first domain of MAdCAM-1 and blocks MAdCAM-1-dependent binding in vitro and lymphocyte homing to Peyer’s patch HEV in vivo. Source of the immunogen was endothelial cells from BALB/c mouse mesenteric and peripheral lymph nodes.
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