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CD43 抗体

SPN 适用: 人 FACS, WB, IHC, IP, Func 宿主: 小鼠 Monoclonal L60 unconjugated
产品编号 ABIN967347
发货至: 中国
  • 抗原 See all CD43 (SPN) 抗体
    CD43 (SPN) (Sialophorin (SPN))
    适用
    • 154
    • 9
    • 9
    宿主
    • 96
    • 68
    • 3
    小鼠
    克隆类型
    • 85
    • 81
    • 1
    单克隆
    标记
    • 62
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    This CD43 antibody is un-conjugated
    应用范围
    • 103
    • 76
    • 62
    • 62
    • 40
    • 17
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    • 14
    • 5
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    Flow Cytometry (FACS), Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Functional Studies (Func)
    品牌
    BD Pharmingen™
    产品特性
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    克隆位点
    L60
    亚型
    IgG1 kappa
    Top Product
    Discover our top product SPN Primary Antibody
  • 限制
    仅限研究用
  • 状态
    Liquid
    浓度
    0.5 mg/mL
    缓冲液
    Aqueous buffered solution containing no preservative.
    储存液
    Without preservative
    储存条件
    4 °C
    储存方法
    This preparation contains no preservatives, thus it should be handled under aseptic conditions. Store undiluted at 4° C.
  • Bazil, Strominger: "CD43, the major sialoglycoprotein of human leukocytes, is proteolytically cleaved from the surface of stimulated lymphocytes and granulocytes." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, Issue 9, pp. 3792-6, (1993) (PubMed).

    Ardman, Sikorski, Staunton: "CD43 interferes with T-lymphocyte adhesion." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 11, pp. 5001-5, (1992) (PubMed).

    Campanero, Pulido, Alonso, Pivel, Pimentel-Muiños, Fresno, Sánchez-Madrid: "Down-regulation by tumor necrosis factor-alpha of neutrophil cell surface expression of the sialophorin CD43 and the hyaluronate receptor CD44 through a proteolytic mechanism." in: European journal of immunology, Vol. 21, Issue 12, pp. 3045-8, (1992) (PubMed).

    Cyster, Williams: "The importance of cross-linking in the homotypic aggregation of lymphocytes induced by anti-leukosialin (CD43) antibodies." in: European journal of immunology, Vol. 22, Issue 10, pp. 2565-72, (1992) (PubMed).

    Kuijpers, Hoogerwerf, Kuijpers, Schwartz, Harlan: "Cross-linking of sialophorin (CD43) induces neutrophil aggregation in a CD18-dependent and a CD18-independent way." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 149, Issue 3, pp. 998-1003, (1992) (PubMed).

    Rieu, Porteu, Bessou, Lesavre, Halbwachs-Mecarelli: "Human neutrophils release their major membrane sialoprotein, leukosialin (CD43), during cell activation." in: European journal of immunology, Vol. 22, Issue 11, pp. 3021-6, (1992) (PubMed).

    Rosenstein, Park, Hahn, Rosen, Bierer, Burakoff: "CD43, a molecule defective in Wiskott-Aldrich syndrome, binds ICAM-1." in: Nature, Vol. 354, Issue 6350, pp. 233-5, (1992) (PubMed).

    Segal, Stoler, Tubbs: "The "CD43 only" phenotype. An aberrant, nonspecific immunophenotype requiring comprehensive analysis for lineage resolution." in: American journal of clinical pathology, Vol. 97, Issue 6, pp. 861-5, (1992) (PubMed).

    Park, Rosenstein, Remold-ODonnell, Bierer, Rosen, Burakoff: "Enhancement of T-cell activation by the CD43 molecule whose expression is defective in Wiskott-Aldrich syndrome." in: Nature, Vol. 350, Issue 6320, pp. 706-9, (1991) (PubMed).

  • 抗原
    CD43 (SPN) (Sialophorin (SPN))
    别名
    CD43 (Leukosialin) (SPN 产品)
    别名
    CD43 antibody, GALGP antibody, GPL115 antibody, LSN antibody, A630014B01Rik antibody, Cd43 antibody, Galgp antibody, Ly-48 antibody, Ly48 antibody, Lsn antibody, Lsn1 antibody, gpL115 antibody, sialophorin antibody, SPN antibody, Spn antibody
    背景
    Anti-leukosialin monoclonal antibody (clone L60) recognizes a sialic acid-dependent determinant on leukosialin, a strongly anionic, highly o-linked glycosylated cell surface protein with a 45 nm extracellular domain. Leukosialin, also know as sialophorin or CD43, is a major component of T lymphocyte, thymocyte, and neutrophil (PMN) membranes, and is also expressed on many different cells including monocytes, platelets, bone marrow stem cells, and plasma cells.
    途径
    Regulation of Leukocyte Mediated Immunity
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