ITK 抗体 (AA 1-26)
(3 references)-
- 抗原 See all ITK 抗体
- ITK (IL2-Inducible T-Cell Kinase (ITK))
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抗原表位
- AA 1-26
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适用
- 人, 小鼠
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This ITK antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunoprecipitation (IP)
- 品牌
- BD Pharmingen™
- 产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Fusion protein with aa.1-26 of human/mouse Itk
- 克隆位点
- 2F12
- 亚型
- IgG1
- Top Product
- Discover our top product ITK Primary Antibody
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anti-IL2-Inducible T-Cell Kinase (ITK) (Internal Region) antibody
Verified ITK 适用: 人, 大鼠 WB, ELISA, IHC, FACS, IF 宿主: 山羊 Polyclonal unconjugated
anti-IL2-Inducible T-Cell Kinase (ITK) antibodyITK 适用: 人 WB, ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 5G6 unconjugated
anti-IL2-Inducible T-Cell Kinase (ITK) (C-Term) antibodyVerified ITK 适用: 人 WB, ELISA, IF 宿主: 山羊 Polyclonal unconjugated
anti-IL2-Inducible T-Cell Kinase (ITK) antibodyITK 适用: 人 WB, ELISA, FACS, IF 宿主: 小鼠 Monoclonal 5G6 unconjugated
anti-IL2-Inducible T-Cell Kinase (ITK) (AA 2-110) antibodyITK 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 5G12C4 unconjugated
anti-IL2-Inducible T-Cell Kinase (ITK) (pTyr512) antibodyITK 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-IL2-Inducible T-Cell Kinase (ITK) (AA 368-625) antibodyITK 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-IL2-Inducible T-Cell Kinase (ITK) antibodyITK 适用: 人 ELISA, IHC 宿主: 兔 Monoclonal 8F10 unconjugated Recombinant Antibody
anti-IL2-Inducible T-Cell Kinase (ITK) (AA 228-262) antibodyITK 适用: 人 WB 宿主: 兔 Polyclonal RB50773 unconjugated
anti-IL2-Inducible T-Cell Kinase (ITK) (AA 156-190), (N-Term) antibodyITK 适用: 小鼠 WB 宿主: 兔 Polyclonal RB50676 unconjugated
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- 说明
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Related Products: ABIN968537
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.5 mg/mL
- 缓冲液
- Aqueous buffered solution containing ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Store undiluted at 4°C.
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: "T cell receptor-initiated calcium release is uncoupled from capacitative calcium entry in Itk-deficient T cells." in: The Journal of experimental medicine, Vol. 187, Issue 10, pp. 1721-7, (1998) (PubMed).
: "Lck phosphorylates the activation loop tyrosine of the Itk kinase domain and activates Itk kinase activity." in: The Journal of biological chemistry, Vol. 272, Issue 40, pp. 25401-8, (1997) (PubMed).
: "itk, a T-cell-specific tyrosine kinase gene inducible by interleukin 2." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 23, pp. 11194-8, (1993) (PubMed).
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: "T cell receptor-initiated calcium release is uncoupled from capacitative calcium entry in Itk-deficient T cells." in: The Journal of experimental medicine, Vol. 187, Issue 10, pp. 1721-7, (1998) (PubMed).
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- 抗原
- ITK (IL2-Inducible T-Cell Kinase (ITK))
- 别名
- ITK (ITK 产品)
- 别名
- Emt antibody, Tcsk antibody, Tsk antibody, EMT antibody, LPFS1 antibody, LYK antibody, PSCTK2 antibody, IL2 inducible T cell kinase antibody, IL2 inducible T-cell kinase antibody, IL2-inducible T-cell kinase antibody, Itk antibody, ITK antibody
- 背景
- Itk (IL-2 inducible tyrosine kinase) is a member of the TEC family of intracellular tyrosine kinases. Members of this family are characterized by their role in hematopoietic cell signaling. Itk is expressed primarily in T cells and has been shown to play a role in T-cell antigen receptor (TCR) mediated proliferation, interleukin-2 production, and T cell differentiation. Itk, following stimulation of the TCR becomes phosphorylated on tyrosine 511 by the Src kinase Lck resulting in increased in vitro Itk kinase activity. If phenylalanine is substituted for tyrosine at position 511, the in vivo kinase activity of Itk is drastically diminished, indicating that this site plays a key role in regulating Itk function. Itk migrates at ~72 kDa on SDS/PAGE. (SWISSPROT: Q08881)
- 分子量
- 72 kDa
- 途径
- TCR Signaling, Fc-epsilon Receptor Signaling Pathway
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