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SLC39A4 抗体 (N-Term)

SLC39A4 适用: 人 IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN967275
发货至: 中国
  • 抗原 See all SLC39A4 抗体
    SLC39A4 (Solute Carrier Family 39 (Zinc Transporter), Member 4 (SLC39A4))
    抗原表位
    • 15
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    适用
    • 35
    • 17
    • 4
    • 2
    • 1
    • 1
    宿主
    • 35
    • 1
    • 1
    克隆类型
    • 37
    多克隆
    标记
    • 20
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SLC39A4 antibody is un-conjugated
    应用范围
    • 32
    • 16
    • 13
    • 13
    • 5
    • 3
    • 3
    • 1
    • 1
    Immunohistochemistry (IHC)
    免疫原
    Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human ZIP4 (Zinc transporter ZIP4)
    Top Product
    Discover our top product SLC39A4 Primary Antibody
  • 限制
    仅限研究用
  • 储存条件
    4 °C
  • Kim, Wang, Dufner-Beattie, Andrews, Eide, Petris: "Zn2+-stimulated endocytosis of the mZIP4 zinc transporter regulates its location at the plasma membrane." in: The Journal of biological chemistry, Vol. 279, Issue 6, pp. 4523-30, (2004) (PubMed).

    Küry, Dréno, Bézieau, Giraudet, Kharfi, Kamoun, Moisan: "Identification of SLC39A4, a gene involved in acrodermatitis enteropathica." in: Nature genetics, Vol. 31, Issue 3, pp. 239-40, (2002) (PubMed).

    Wang, Zhou, Kuo, Zemansky, Gitschier: "A novel member of a zinc transporter family is defective in acrodermatitis enteropathica." in: American journal of human genetics, Vol. 71, Issue 1, pp. 66-73, (2002) (PubMed).

  • 抗原
    SLC39A4 (Solute Carrier Family 39 (Zinc Transporter), Member 4 (SLC39A4))
    别名
    ZIP4 (SLC39A4 产品)
    别名
    AEZ antibody, AWMS2 antibody, ZIP4 antibody, 1600025H15Rik antibody, AU041686 antibody, solute carrier family 39 member 4 antibody, solute carrier family 39 (zinc transporter), member 4 antibody, SLC39A4 antibody, slc39a4 antibody, Slc39a4 antibody
    背景
    ZIP4 (Zinc transporter ZIP4) plays an important role in cellular zinc homeostasis as a zinc transporter. ZIP4 is regulated in response to zinc availability. ZIP4 is a multi-pass membrane protein and is colocalized with TFRC in the recycling endosomes. ZIP4 cycles between endosomal compartments and the plasma membrane in response to zinc availability. ZIP4 is highly expressed in kidney, small intestine, stomach, colon, jejunum and duodenum. Defects in SLC39A4 are the cause of acrodermatitis enteropathica zinc-deficiency type (AEZ). AEZ is a rare autosomal recessive disease caused by the inability to absorb sufficient zinc. The clinicals features are growth retardation, immune system dysfunction, alopecia, severe dermatitis, diarrhea and occasionally mental disorders. All these manifestations are reversible with zinc supplementation. Without zinc therapy this disease is fatal. ZIP4 belongs to the ZIP transporter (TC 2.A.5) family.
    Synonyms: SLC39A4 (Solute carrier family 39 member 4), ZIP-4 (Zrt- and Irt-like protein 4)
    途径
    Transition Metal Ion Homeostasis, Autophagy
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