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Vimentin 抗体

VIM 适用: 人 WB, IHC, ELISA 宿主: 小鼠 Monoclonal 9E7E7-5G3F10-5G3F10E5 unconjugated
产品编号 ABIN967252
发货至: 中国
  • 抗原 See all Vimentin (VIM) 抗体
    Vimentin (VIM)
    适用
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    宿主
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    小鼠
    克隆类型
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    单克隆
    标记
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    This Vimentin antibody is un-conjugated
    应用范围
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    Western Blotting (WB), Immunohistochemistry (IHC), ELISA
    纯化方法
    Ascitic fluid
    免疫原
    Purified recombinant fragment of Vimentin expressed in E. Coli.
    克隆位点
    9E7E7-5G3F10-5G3F10E5
    亚型
    IgG1
    Top Product
    Discover our top product VIM Primary Antibody
  • 应用备注
    Western Bloting: 1/500 - 1/2000.
    Immunohistochemistry: 1/200 - 1/1000.
    ELISA: Propose dilution 1/10000.
    Not yet tested in other applications.
    Determining optimal working dilutions by titration test.
    限制
    仅限研究用
  • 状态
    Liquid
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
  • Vanzi: "Freedom at home: state constitutions and Medicaid funding for abortions." in: New Mexico law review, Vol. 26, Issue 3, pp. 433-54, (2005) (PubMed).

  • 抗原
    Vimentin (VIM)
    别名
    Vimentin (VIM 产品)
    别名
    CTRCT30 antibody, cb28 antibody, vime antibody, vim antibody, vim1 antibody, vim2 antibody, VIM antibody, Vimentin antibody, vim4 antibody, vimentin antibody, vimentin L homeolog antibody, vimentin S homeolog antibody, VIM antibody, Vim antibody, vim antibody, vim.L antibody, vim.S antibody
    背景
    Vimentin is the major subunit protein of the intermediate filaments of mesenchymal cells. It is believed to be involved with the intracellular transport of proteins between the nucleus and plasma membrane. Vimentin has been implicated to be involved in the rate of steroid synthesis via its role as a storage network for steroidogenic cholesterol containing lipid droplets. Vimentin phosphorylation by a protein kinase causes the breakdown of intermediate filaments and activation of an ATP and myosin light chain dependent contractile event. This results in cytoskeletal changes that facilitate the interaction of the lipid droplets within mitochondria, and subsequent transport of cholesterol to the organelles leading to an increase in steroid synthesis. Immunohistochemical staining for Vimentin is characteristic of sarcomas (of neural, muscle and fibroblast origin) compared to carcinomas which are generally negative. Melanomas, lymphomas and vascular tumors may all stain for Vimentin. Vimentin antibodies are thus of value in the differential diagnosis of undifferentiated neoplasms and malignant tumors. They are generally used with a panel of other antibodies including those recognising cytokeratins, lymphoid markers, S100, desmin and neurofilaments.
    Synonyms: FLJ36605, VIM
    基因ID
    7431
    途径
    Caspase Cascade in Apoptosis
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