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TRPV1 抗体 (Middle Region)

TRPV1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN967211
发货至: 中国
  • 抗原 See all TRPV1 抗体
    TRPV1 (Transient Receptor Potential Cation Channel, Subfamily V, Member 1 (TRPV1))
    抗原表位
    • 8
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    适用
    • 38
    • 28
    • 24
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    宿主
    • 53
    • 6
    • 2
    • 2
    克隆类型
    • 58
    • 5
    多克隆
    标记
    • 40
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    This TRPV1 antibody is un-conjugated
    应用范围
    • 32
    • 24
    • 13
    • 7
    • 7
    • 6
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    交叉反应
    小鼠, 大鼠
    交叉反应 (详细)
    No cross reactivity with other proteins.
    产品特性
    Rabbit IgG polyclonal antibody for Transient receptor potential cation channel subfamily V member 1 ( TRPV1) detection. Tested with WB, IHC-P in Human, Mouse, Rat.
    免疫原
    A synthetic peptide corresponding to a sequence in the middle region of human TRPV1, identical to the related rat and mouse sequences.< br/>Immunogen was affinity purified.
    亚型
    IgG
    Top Product
    Discover our top product TRPV1 Primary Antibody
  • 限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
    缓冲液
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    储存液
    Sodium azide, Thimerosal (Merthiolate)
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    -20 °C
    储存方法
    At -20 °C for one year. After reconstitution, at 4 °C for one month. It can also be aliquotted and stored frozen at -20 °C for a longer time.
  • Cui, Honore, Zhong, Gauvin, Mikusa, Hernandez, Chandran, Gomtsyan, Brown, Bayburt, Marsh, Bianchi, McDonald, Niforatos, Neelands, Moreland, Decker, Lee, Sullivan, Faltynek: "TRPV1 receptors in the CNS play a key role in broad-spectrum analgesia of TRPV1 antagonists." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 26, Issue 37, pp. 9385-93, (2006) (PubMed).

    Birder, Nakamura, Kiss, Nealen, Barrick, Kanai, Wang, Ruiz, De Groat, Apodaca, Watkins, Caterina: "Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1." in: Nature neuroscience, Vol. 5, Issue 9, pp. 856-60, (2002) (PubMed).

    Xue, Yu, Trilk, Jong, Schumacher: "The genomic organization of the gene encoding the vanilloid receptor: evidence for multiple splice variants." in: Genomics, Vol. 76, Issue 1-3, pp. 14-20, (2001) (PubMed).

    Eisenberg, Gresalfi, Riccio, McLaughlin: "Adsorption of monovalent cations to bilayer membranes containing negative phospholipids." in: Biochemistry, Vol. 18, Issue 23, pp. 5213-23, (1980) (PubMed).

  • 抗原
    TRPV1 (Transient Receptor Potential Cation Channel, Subfamily V, Member 1 (TRPV1))
    别名
    Transient receptor potential cation channel subfamily V member 1 (TRPV1) (TRPV1 产品)
    别名
    si:dkey-9e15.2 antibody, VR.5'sv antibody, Vr1 antibody, Vr1l1 antibody, VR1 antibody, OTRPC1 antibody, TRPV1alpha antibody, TRPV1beta antibody, VR-1 antibody, transient receptor potential cation channel, subfamily V, member 1 antibody, transient receptor potential cation channel subfamily V member 1 antibody, trpv1 antibody, Trpv1 antibody, TRPV1 antibody
    背景
    The transient receptor potential cation channel, subfamily V, member 1 (TRPV1), also known as the capsaicin receptor is a protein which in humans is encoded by the TRPV1 gene. TRPV1 (also called Vanilloid receptor type 1) is a ligand-gated nonselective cation channel that is considered to be an important integrator of various pain stimuli such as endogenous lipids, capsaicin, heat, and low pH. In addition to expression in primary afferents, TRPV1 is also expressed in the CNS. Cui M et al. (2006) demonstrate that TRPV1 receptors in the CNS play an important role in pain mediated by central sensitization. And the significant CNS penetration is necessary for a TRPV1 antagonist to produce broad-spectrum analgesia. And TRPV1 also participates in normal bladder function and is essential for normal mechanically evoked purinergic signaling by the urothelium.
    途径
    Dicarboxylic Acid Transport
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