(3 references)-
- 抗原 See all TRKA (NTRK1) 抗体
- TRKA (NTRK1) (Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1))
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抗原表位
- Middle Region
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This TRKA antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 交叉反应
- 小鼠, 大鼠
- 交叉反应 （详细）
- No cross reactivity with other proteins.
- 产品特性
- Rabbit IgG polyclonal antibody for High affinity nerve growth factor receptor ( NTRK1) detection. Tested with WB, IHC-P in Human, Mouse, Rat.
- 免疫原
- A synthetic peptide corresponding to a sequence in the middle region of human NTRK1, identical to the related rat and mouse sequences.< br/>Immunogen was affinity purified.
- 亚型
- IgG
- Top Product
- Discover our top product NTRK1 Primary Antibody
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anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (pTyr681), (Tyr680) antibody
NTRK1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (AA 725-821) antibodyNTRK1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), FACS, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (AA 33-208) antibodyNTRK1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) antibodyNTRK1 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (Extracellular Domain) antibodyNTRK1 适用: 人 WB, ELISA, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (C-Term) antibodyNTRK1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (AA 769-796) antibodyNTRK1 适用: 人 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) antibodyNTRK1 适用: 人, 小鼠 WB, ELISA, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (2nd Extracellular Domain), (AA 342-356) antibodyNTRK1 适用: 人, 小鼠, 大鼠 WB, IHC, IF, FACS, ICC, LCI 宿主: 兔 Polyclonal unconjugated
anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (pTyr496) antibodyNTRK1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
- 缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
- 储存液
- Sodium azide, Thimerosal (Merthiolate)
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- -20 °C
- 储存方法
- At -20 °C for one year. After reconstitution, at 4 °C for one month. It can also be aliquotted and stored frozen at -20 °C for a longer time.
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: "Molecular basis for keratoconus: lack of TrkA expression and its transcriptional repression by Sp3." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 46, pp. 16795-800, (2005) (PubMed).
: "Mutations in the TRKA/NGF receptor gene in patients with congenital insensitivity to pain with anhidrosis." in: Nature genetics, Vol. 13, Issue 4, pp. 485-8, (1996) (PubMed).
: "Circulating nerve growth factor levels are increased in humans with allergic diseases and asthma." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, Issue 20, pp. 10955-60, (1996) (PubMed).
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: "Molecular basis for keratoconus: lack of TrkA expression and its transcriptional repression by Sp3." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 46, pp. 16795-800, (2005) (PubMed).
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- 抗原
- TRKA (NTRK1) (Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1))
- 别名
- High affinity nerve growth factor receptor (NTRK1) (NTRK1 产品)
- 别名
- MTC antibody, TRK antibody, TRK1 antibody, TRKA antibody, Trk-A antibody, p140-TrkA antibody, CDHF12 antibody, CDHR16 antibody, HSCR1 antibody, MEN2A antibody, MEN2B antibody, MTC1 antibody, PTC antibody, RET-ELE1 antibody, RET51 antibody, Trk antibody, C80751 antibody, Tkr antibody, TrkA antibody, trk antibody, trka antibody, CTRKA antibody, trkA antibody, neurotrophic receptor tyrosine kinase 1 antibody, ret proto-oncogene antibody, neurotrophic tyrosine kinase, receptor, type 1 antibody, NTRK1 antibody, RET antibody, Ntrk1 antibody, ntrk1 antibody
- 背景
- Trk A (Neurotrophic tyrosine kinase receptor A) is the high affinity catalytic receptor for the neurotrophin, Nerve Growth Factor (NGF). Higher affinity binding of NGFR can achieved by association with higher molecular mass, low-affinity neurotrophin receptors, namely the tropomyosin receptor kinases, TRKA (NTRK1), TRKB (NTRK2), and TRKC (NTRK3). TRKA, TRKB, and TRKC are specific for or 'preferred by' NGF, NTF4 (Neurotrophin-4) and BDNF, and NTF3 (Neurotrophin-3), respectively. NTF3 also binds to TRKA and TRKB, but with significantly lower affinity. The absence of TrkA (NGFR) expression was associated with a strong increase in the Sp3 repressor short isoform (s) and a lack of the Sp3 activator long isoform. Sp3 is a bifunctional transcription factor that has been reported to stimulate or repress the transcription of numerous genes. Indo et al. (1996) concluded that defects in TRKA cause CIPA (Congenital insensitivity to pain with anhidrosis ) and that the NGF-TRKA system has a crucial role in the development and function of the nociceptive reception as well as establishment of thermoregulation via sweating in humans. These results also implicate genes encoding other TRK and neurotrophin family members as candidates for developmental defect (s) of the nervous system.
- 途径
- RTK signaling, Neurotrophin Signaling Pathway, cAMP Metabolic Process
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