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SOCS2 抗体 (C-Term)

SOCS2 适用: 人, 大鼠 WB Polyclonal unconjugated
产品编号 ABIN967065
发货至: 中国
  • 抗原 See all SOCS2 抗体
    SOCS2 (Suppressor of Cytokine Signaling 2 (SOCS2))
    抗原表位
    • 8
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 181-198, C-Term
    适用
    • 43
    • 20
    • 10
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    人, 大鼠
    宿主
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    克隆类型
    • 35
    • 11
    多克隆
    标记
    • 25
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    This SOCS2 antibody is un-conjugated
    应用范围
    • 20
    • 14
    • 8
    • 8
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    免疫原
    A synthetic peptide corresponding to a sequence at the C-terminal of human SOCS2 (181-198 aa), identical to the related mouse and rat sequence.
    Top Product
    Discover our top product SOCS2 Primary Antibody
  • 限制
    仅限研究用
  • 溶解方式
    0.2ml of distilled water will yield a concentration of 500µg/ml.
    缓冲液
    Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4
    储存液
    Thimerosal (Merthiolate), Sodium azide
    储存条件
    -20 °C
  • Greenhalgh, Bertolino, Asa, Metcalf, Corbin, Adams, Davey, Nicola, Hilton, Alexander: "Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b)." in: Molecular endocrinology (Baltimore, Md.), Vol. 16, Issue 6, pp. 1394-406, (2002) (PubMed).

    Dey, Spence, Nissley, Furlanetto: "Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor." in: The Journal of biological chemistry, Vol. 273, Issue 37, pp. 24095-101, (1998) (PubMed).

    Masuhara, Sakamoto, Matsumoto, Suzuki, Yasukawa, Mitsui, Wakioka, Tanimura, Sasaki, Misawa, Yokouchi, Ohtsubo, Yoshimura: "Cloning and characterization of novel CIS family genes." in: Biochemical and biophysical research communications, Vol. 239, Issue 2, pp. 439-46, (1997) (PubMed).

    Minamoto, Ikegame, Ueno, Narazaki, Naka, Yamamoto, Matsumoto, Saito, Hosoe, Kishimoto: "Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3." in: Biochemical and biophysical research communications, Vol. 237, Issue 1, pp. 79-83, (1997) (PubMed).

  • 抗原
    SOCS2 (Suppressor of Cytokine Signaling 2 (SOCS2))
    别名
    SOCS2 (SOCS2 产品)
    别名
    CIS2 antibody, Cish2 antibody, SOCS-2 antibody, SSI-2 antibody, SSI2 antibody, STATI2 antibody, Cish1 antibody, Socs-1 antibody, Socs-2 antibody, si:dkey-202b22.1 antibody, socs2 antibody, cis2 antibody, ssi2 antibody, cish2 antibody, ssi-2 antibody, socs-2 antibody, stati2 antibody, 8030460M17 antibody, AI527257 antibody, AW108012 antibody, D130043N08Rik antibody, JAB antibody, hg antibody, Cradd antibody, Socs2 antibody, suppressor of cytokine signaling 2 antibody, suppressor of cytokine signaling 1 antibody, death domain-containing protein CRADD antibody, suppressor of cytokine signaling 2 S homeolog antibody, SOCS2 antibody, Socs1 antibody, Socs2 antibody, socs2 antibody, LOC100716104 antibody, socs2.S antibody
    背景
    Suppressor of cytokine signaling 2 is a protein that in humans is encoded by the SOCS2 gene. This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signalling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10 and interferon-gamma (IFN-gamma). The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor 1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling. Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control. By cytogenetic and radiation hybrid mapping, Yandava et al. (1999) mapped the SOCS2 gene to chromosome 12q21.3-q23.
    途径
    JAK/STAT Signaling, Response to Growth Hormone Stimulus
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