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SMAD2 抗体

SMAD2 适用: 人 WB, ELISA, IHC, IF, FACS 宿主: 小鼠 Monoclonal 5G7 unconjugated
产品编号 ABIN967045
发货至: 中国
  • 抗原 See all SMAD2 抗体
    SMAD2 (SMAD, Mothers Against DPP Homolog 2 (SMAD2))
    适用
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    宿主
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    小鼠
    克隆类型
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    单克隆
    标记
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    This SMAD2 antibody is un-conjugated
    应用范围
    • 211
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    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)
    纯化方法
    Ascitic fluid
    免疫原
    Purified recombinant fragment of human SMAD2 expressed in E. Coli.
    克隆位点
    5G7
    亚型
    IgG1
    Top Product
    Discover our top product SMAD2 Primary Antibody
  • 应用备注
    Western Bloting: 1/500 - 1/2000.
    Immunohistochemistry: 1/200 - 1/1000.
    Immunofluorescence: 1/200 - 1/1000.
    Flow cytometry: 1/200 - 1/400.
    ELISA: Propose dilution 1/10000.
    Not yet tested in other applications.
    Determining optimal working dilutions by titration test.
    限制
    仅限研究用
  • 状态
    Liquid
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
  • Hannan, Jamshidi, Pera, Wolvetang: "BMP-11 and myostatin support undifferentiated growth of human embryonic stem cells in feeder-free cultures." in: Cloning and stem cells, Vol. 11, Issue 3, pp. 427-35, (2009) (PubMed).

  • 抗原
    SMAD2 (SMAD, Mothers Against DPP Homolog 2 (SMAD2))
    别名
    SMAD2 (SMAD2 产品)
    别名
    JV18 antibody, JV18-1 antibody, MADH2 antibody, MADR2 antibody, hMAD-2 antibody, hSMAD2 antibody, jv18 antibody, Xmad2 antibody, madh2 antibody, madr2 antibody, XSmad2 antibody, hmad-2 antibody, hsmad2 antibody, jv18-1 antibody, smad-2 antibody, fj43c06 antibody, wu:fj43c06 antibody, 7120426M23Rik antibody, Madh2 antibody, Madr2 antibody, Smad-2 antibody, mMad2 antibody, MAD homolog 2 antibody, Mothers against DPP homolog 2 antibody, SMAD 2 antibody, Smad2 antibody, SMAD family member 2 antibody, SMAD family member 2-Z antibody, SMAD family member 2 S homeolog antibody, SMAD2 antibody, SMAD2Z antibody, smad2 antibody, smad2.S antibody, Smad2 antibody
    背景
    The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants encoding the same protein have been observed.
    Synonyms: JV18, MADH2, MADR2, JV18-1, hMAD-2, hSMAD2, MGC22139, MGC34440
    分子量
    52kDa
    基因ID
    4087
    途径
    Cell Division Cycle, Hormone Transport, Chromatin Binding, Protein targeting to Nucleus
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