电话:
400-7060-959
传真:
+86 10 56315212-8813
电子邮件:
orders@antibodies-online.cn

RICTOR 抗体

RICTOR 适用: 人, 小鼠, 猴 WB, ELISA 宿主: 小鼠 Monoclonal 4H5 unconjugated
产品编号 ABIN966967
发货至: 中国
  • 抗原 See all RICTOR 抗体
    RICTOR (RPTOR Independent Companion of mTOR, Complex 2 (RICTOR))
    适用
    • 65
    • 33
    • 3
    • 2
    • 1
    人, 小鼠, 猴
    宿主
    • 59
    • 6
    • 1
    小鼠
    克隆类型
    • 59
    • 7
    单克隆
    标记
    • 39
    • 4
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This RICTOR antibody is un-conjugated
    应用范围
    • 51
    • 38
    • 27
    • 11
    • 8
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA
    纯化方法
    Ascitic fluid
    免疫原
    Purified recombinant fragment of human RICTOR expressed in E. Coli.
    克隆位点
    4H5
    亚型
    IgG1
    Top Product
    Discover our top product RICTOR Primary Antibody
  • 应用备注
    Western Bloting: 1/500 - 1/2000.
    ELISA: Propose dilution 1/10000.
    Not yet tested in other applications.
    Determining optimal working dilutions by titration test.
    限制
    仅限研究用
  • 状态
    Liquid
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
  • Martin, Masri, Bernath, Nishimura, Gera: "Hsp70 associates with Rictor and is required for mTORC2 formation and activity." in: Biochemical and biophysical research communications, Vol. 372, Issue 4, pp. 578-83, (2008) (PubMed).

    Yang, Inoki, Ikenoue, Guan: "Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity." in: Genes & development, Vol. 20, Issue 20, pp. 2820-32, (2006) (PubMed).

  • 抗原
    RICTOR (RPTOR Independent Companion of mTOR, Complex 2 (RICTOR))
    别名
    RICTOR (RICTOR 产品)
    别名
    PIA antibody, mAVO3 antibody, 4921505C17Rik antibody, 6030405M08Rik antibody, AVO3 antibody, AW492497 antibody, D530039E11Rik antibody, Fyb antibody, RPTOR independent companion of MTOR complex 2 antibody, RPTOR independent companion of MTOR, complex 2 antibody, RICTOR antibody, Rictor antibody
    背景
    Cell growth is a fundamental biological process whereby cells accumulate mass and increase in size. The mammalian TOR (mTOR) pathway regulates growth by coordinating energy and nutrient signals with growth factor-derived signals . mTOR is a large protein kinase with two different complexes. One complex contains mTOR, µL and raptor, which is a target of rapamycin. The other complex, insensitive to rapamycin, includes mTOR, µL, Sin1 and rictor. The mTOR-rictor complex phosphorylates Ser473 of Akt/PKB in vitro . This phosphorylation is essential for full Akt/PKB activation. Furthermore, an siRNA knockdown of rictor inhibits Ser473 phosphorylation in 3T3-L1 adipocytes. This complex has also been shown to phosphorylate the rapamycinresistant mutants of S6K1, another effector of mTOR .
    Synonyms: PIA, mAVO3, KIAA1999, MGC39830, DKFZp686B11164, RICTOR
    分子量
    192kDa
    基因ID
    253260
    途径
    Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Actin Filament Polymerization, CXCR4-mediated Signaling Events
You are here:
客服