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LIM and Senescent Cell Antigen-Like Domains 1 (LIMS1) 抗体

ABIN966832 产品详细信息, 供应商: Log in to see
抗原
  • PINCH
  • PINCH-1
  • PINCH1
  • Pinch1
  • RGD1560732
  • LIMS3
  • LIMS3L
  • 2310016J22Rik
  • 4921524A02Rik
  • AI507642
  • AU021743
  • AW551584
  • C430041B13Rik
  • Lims1l
  • LIM and senescent cell antigen-like domains 1
  • LIMS1
  • Lims1
适用

53
32
32
5
4
4
4
4
4
3
3
2
2
2
宿主
小鼠
43
11
克隆类型 (克隆位点)
单克隆 ()
标记
非结合性
2
2
1
1
1
1
1
1
1
1
1
1
1
1
应用范围
Flow Cytometry (FACS), Immunofluorescence (IF), ELISA, Western Blotting (WB)
38
18
13
13
8
8
6
5
3
1
1
1
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免疫原 Purified recombinant fragment of human PINCH expressed in E. Coli.
克隆位点 5G7
亚型 IgG1
纯化方法 Ascitic fluid
别名 PINCH (LIMS1 Antibody 摘要)
背景 The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene.
Synonyms: PINCH, PINCH1, PINCH-1, LIMS1
分子量 37kDa
基因ID 3987
应用备注 Western Bloting: 1/500 - 1/2000.
Immunofluorescence: 1/200 - 1/1000.
Flow cytometry: 1/200 - 1/400.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
限制 仅限研究用
状态 Liquid
储存液 Sodium azide
注意事项 This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件 4 °C
有引用在: Yang, Wang, Hawkins, Chen, Vaynberg, Mao, Tu, Zuo, Wang, Wang, Wu, Tjandra, Qin: "Structural basis of focal adhesion localization of LIM-only adaptor PINCH by integrin-linked kinase." in: The Journal of biological chemistry, Vol. 284, Issue 9, pp. 5836-44, 2009 (PubMed).

Chiswell, Zhang, Murphy, Boggon, Calderwood: "The structural basis of integrin-linked kinase-PINCH interactions." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 52, pp. 20677-82, 2008 (PubMed).