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- 抗原 See all NFKB2 抗体
- NFKB2 (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 2 (NFKB2))
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抗原表位
- Middle Region
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This NFKB2 antibody is un-conjugated
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应用范围
- Immunohistochemistry (IHC)
- 免疫原
- Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to middle amino acid residues of human NFKB2 (Nuclear factor NF-kappa-B p100 subunit)
- Top Product
- Discover our top product NFKB2 Primary Antibody
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- 限制
- 仅限研究用
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- 储存条件
- 4 °C
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A new member of the I kappaB protein family, I kappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription." in: Molecular and cellular biology, Vol. 17, Issue 10, pp. 6184-90, (1997) (PubMed).
: "Differential interactions of Rel-NF-kappa B complexes with I kappa B alpha determine pools of constitutive and inducible NF-kappa B activity." in: The EMBO journal, Vol. 13, Issue 19, pp. 4608-16, (1994) (PubMed).
: "Activation of multiple NF-kappa B/Rel DNA-binding complexes by tumor necrosis factor." in: Oncogene, Vol. 9, Issue 5, pp. 1487-92, (1994) (PubMed).
: "Purification of the major histocompatibility complex class I transcription factor H2TF1. The full-length product of the nfkb2 gene." in: The Journal of biological chemistry, Vol. 268, Issue 25, pp. 18882-90, (1993) (PubMed).
: "The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers." in: Cell, Vol. 72, Issue 5, pp. 729-39, (1993) (PubMed).
: "A novel mitogen-inducible gene product related to p50/p105-NF-kappa B participates in transactivation through a kappa B site." in: Molecular and cellular biology, Vol. 12, Issue 2, pp. 685-95, (1992) (PubMed).
: "Cloning of an NF-kappa B subunit which stimulates HIV transcription in synergy with p65." in: Nature, Vol. 352, Issue 6337, pp. 733-6, (1991) (PubMed).
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A new member of the I kappaB protein family, I kappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription." in: Molecular and cellular biology, Vol. 17, Issue 10, pp. 6184-90, (1997) (PubMed).
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- 抗原
- NFKB2 (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 2 (NFKB2))
- 别名
- NFKB2 (NFKB2 产品)
- 背景
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NFKB2 (Nuclear factor NF-kappa-B p100 subunit) is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappaB sites that they can bind with distinguishable affinity and specificity. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function.
Synonyms: LYT10(Lymphocyte translocation chromosome 10) - 途径
- Toll-Like Receptors Cascades
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