(3 references)-
- 抗原
- KSHVORF45
- 适用
- Human Herpesvirus 8 (HHV-8)
- 宿主
- 请咨询
-
克隆类型
- 单克隆
-
标记
- 非结合性
-
应用范围
- ELISA, Western Blotting (WB)
- 特异性
- Ni-NTA purified recombinant human KSHV ORF45 expressed in E. Coli strain BL21 (DE3).
- 纯化方法
- Crude ascites.
- 亚型
- IgG1
-
anti-KSHVORF45 antibody
适用: Human Herpesvirus 8 (HHV-8) ELISA, WB, IHC 宿主: 小鼠 Monoclonal 2D4A5 unconjugated
-
- 应用备注
-
Dilution: Western Blot: 1:500-1,000
ELISA: Determining optimal working dilutions by titration test. - 限制
- 仅限研究用
-
- 储存条件
- -20 °C
-
-
: "The ORF45 protein of Kaposi's sarcoma-associated herpesvirus is associated with purified virions." in: Journal of virology, Vol. 77, Issue 7, pp. 4221-30, (2003) (PubMed).
: "A Kaposi's sarcoma-associated herpesviral protein inhibits virus-mediated induction of type I interferon by blocking IRF-7 phosphorylation and nuclear accumulation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 8, pp. 5573-8, (2002) (PubMed).
: "Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma." in: Science (New York, N.Y.), Vol. 266, Issue 5192, pp. 1865-9, (1995) (PubMed).
-
: "The ORF45 protein of Kaposi's sarcoma-associated herpesvirus is associated with purified virions." in: Journal of virology, Vol. 77, Issue 7, pp. 4221-30, (2003) (PubMed).
-
- 抗原
- KSHVORF45
- 物质类
- Viral Protein
- 背景
- Kaposi's sarcoma-associated herpesvirus (KSHV) belongs to the gamma-(2)-herpesvirus subfamily and has been closely linked to the Kaposi's sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman's disease. The genome of KSHV is 165-170 kb and contains at least 88 open reading frames. ORF45 protein encoded by an immediateearly gene in the KSHV genome is characterized as a phosphorylated protein, and it is localized in the cytoplasm of infected cells. Studies have shown that ORF45 Protein interacted with cellular IRF-7 and blocked virus-mediated phosphorylation and nuclear translocation of IRF-7. In consequence, ORF45 efficiently inhibited virus-induced production of type I IFN. Zhu et al (2003) reported that the ORF45 Protein was associated with purified virions
-
You are here:
