(3 references)-
- 抗原 See all USP7 抗体
- USP7 (Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This USP7 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 纯化方法
- Ascitic fluid
- 免疫原
- Purified recombinant fragment of human HAUSP expressed in E. Coli.
- 克隆位点
- 5F11
- 亚型
- IgG1
- Top Product
- Discover our top product USP7 Primary Antibody
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anti-Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) (AA 54-507) antibody
USP7 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) antibodyUSP7 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Monoclonal 7F10 unconjugated Recombinant Antibody
anti-Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) (AA 206-1102) antibodyUSP7 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) (AA 206-1102) antibodyUSP7 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) antibodyUSP7 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) (Internal Region) antibodyUSP7 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) (AA 1050-1100) antibodyUSP7 适用: 人, 小鼠, 大鼠, 犬, 马, 小鸡, Macaque WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) (AA 258-483) antibodyUSP7 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) (AA 302-394), (C-Term) antibodyUSP7 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) (AA 30-80) antibodyUSP7 适用: 人, 小鼠, 大鼠, 犬, 马, 小鸡, Macaque WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test. - 限制
- 仅限研究用
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- 状态
- Liquid
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
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: "Expression of DNA repair and replication genes in non-small cell lung cancer (NSCLC): a role for thymidylate synthetase (TYMS)." in: BMC cancer, Vol. 12, Issue 1, pp. 342, (2012) (PubMed).
: "[Treatment of airway inflammation in cystic fibrosis]." in: Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, Vol. 14, Issue 11, pp. 1350-5, (2007) (PubMed).
: "Observations on a case of probable bone marrow anthracosis." in: Blood, Vol. 14, pp. 1350-3 (PubMed).
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: "Expression of DNA repair and replication genes in non-small cell lung cancer (NSCLC): a role for thymidylate synthetase (TYMS)." in: BMC cancer, Vol. 12, Issue 1, pp. 342, (2012) (PubMed).
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- 抗原
- USP7 (Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7))
- 别名
- HAUSP (USP7 产品)
- 别名
- CG1490 antibody, Dmel\\CG1490 antibody, USP7 antibody, 2210010O09Rik antibody, AA409944 antibody, AA617399 antibody, AU019296 antibody, AW548146 antibody, C80752 antibody, Hausp antibody, HAUSP antibody, TEF1 antibody, UBP antibody, Ubiquitin-specific protease 7 antibody, ubiquitin carboxyl-terminal hydrolase 7 antibody, ubiquitin specific peptidase 7 antibody, Usp7 antibody, LOC100201254 antibody, USP7 antibody
- 背景
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USP7 or HAUSP is a ubiquitin specific protease or a deubiquitylating enzyme that cleaves ubiquitin from its substrates. Since ubiquitylation (polyubiquitination) is most commonly associated with the stability and degradation of cellular proteins, HAUSP acitivity generally stabilizes its substrate proteins. HAUSP is most popularly known as a direct antagonist of Mdm2, the E3 ubiquitin ligase for the tumor suppressor protein, p53.Normally, p53 levels are kept low in part due to Mdm2mediated ubiquitylation and degradation of p53. Interestingly, in response to oncogenic insults, HAUSP can deubiquitinate p53 and protect p53 from Mdm2-mediated degradation, indicating that it may possess a tumor suppressor function for the immediate stabilization of p53 in response to stress. Another important role of HAUSP function involves the oncogenic stabilization of p53. Oncogenes such as Myc and E1A are thought to activate p53 through a p19 alternative reading frame (p19ARF, also called ARF)dependent pathway, although some evidence suggests ARF is not essential in this process. An intriguing possibility is that HAUSP provides an alternative pathway for safeguarding the cell against oncogenic insults.
Synonyms: TEF1, HAUSP, USP7 - 分子量
- 128kDa
- 基因ID
- 7874
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