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FES 抗体

Cited in 1 publication. The 小鼠 单克隆 anti-FES antibody (Clone 5A11G5) (ABIN966135) specifically detects FES in WB 和 ELISA. The antibody is reactive with 人 samples.
产品编号 ABIN966135
发货至: 中国
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Quick Overview for FES 抗体 (ABIN966135)

抗原

See all FES 抗体
FES (Feline Sarcoma Oncogene (FES))

适用

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宿主

  • 37
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小鼠

克隆类型

  • 39
  • 5
单克隆

标记

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This FES antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA

克隆位点

5A11G5
  • 纯化方法

    Ascitic fluid

    免疫原

    Purified recombinant fragment of FES expressed in E. Coli.

    亚型

    IgG1
  • 应用备注

    Western Bloting: 1/500 - 1/2000.
    ELISA: Propose dilution 1/10000.
    Not yet tested in other applications.
    Determining optimal working dilutions by titration test.

    限制

    仅限研究用
  • 状态

    Liquid

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C
  • Vitenzon, Mironov, Petrushanskaya: "Functional electrostimulation of muscles as a method for restoring motor functions." in: Neuroscience and behavioral physiology, Vol. 35, Issue 7, pp. 709-14, (2006) (PubMed).

  • 抗原

    FES (Feline Sarcoma Oncogene (FES))

    别名

    FES

    背景

    FES (feline sarcoma oncogene) and Fer are the only two members of a unique family of cytoplasmic protein tyrosine kinases. FES and Fer contain a central Src homology-2 (SH2) domain and a carboxy-terminal tyrosine kinase catalytic domain. They are structurally distinguished from other members of cytoplasmic protein tyrosine kinase subfamilies by the presence of amino-terminal Fer/CIP4 homology and coiled-coil domains. FES was originally identified as an oncogene from avian and feline retroviruses. Human c-Fes has been implicated in myeloid, vascular endothelial and neuronal cell differentiation. FES has tyrosinespecific protein kinase activity and that activity is required for maintenance of cellular transformation. Mutations may activate the FES kinase and thereby contribute to cancer. However, recent data strongly suggests that the c-FES protein-tyrosine kinase is a tumor suppressor rather than a dominant oncogene in colorectal cancer.
    Synonyms: FPS

    基因ID

    2242

    途径

    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Signaling Events mediated by VEGFR1 and VEGFR2
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