HCV E2 抗体 (N-Term)
HCV E2
适用: Hepatitis C Virus (HCV)
IHC
宿主: 兔
Polyclonal
unconjugated
(2 references)-
- 抗原 See all HCV E2 抗体
- HCV E2 (Hepatitis C Virus Envelope Protein E2 (HCV E2))
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抗原表位
- N-Term
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适用
- Hepatitis C Virus (HCV)
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This HCV E2 antibody is un-conjugated
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应用范围
- Immunohistochemistry (IHC)
- 纯化方法
- Purified by antigen-specific affinity chromatography.
- 免疫原
- Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of Hepatitis C virus envelope E2 protein.
- Top Product
- Discover our top product HCV E2 Primary Antibody
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anti-Hepatitis C Virus Envelope Protein E2 (HCV E2) (AA 412-661) antibody
HCV E2 适用: Hepatitis C Virus (HCV) WB, ELISA 宿主: 小鼠 Monoclonal 2G1 unconjugated
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- 应用备注
- ELISA, Western blotting: 1µg/ml for 2hrs.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- This antibody is stored in PBS, 50% glycerol
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
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: "Experimental infection of chimpanzees with hepatitis C virus of genotype 5a: genetic analysis of the virus and generation of a standardized challenge pool." in: The Journal of infectious diseases, Vol. 178, Issue 4, pp. 1193-7, (1998) (PubMed).
: "Transmission of hepatitis C by intrahepatic inoculation with transcribed RNA." in: Science (New York, N.Y.), Vol. 277, Issue 5325, pp. 570-4, (1997) (PubMed).
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: "Experimental infection of chimpanzees with hepatitis C virus of genotype 5a: genetic analysis of the virus and generation of a standardized challenge pool." in: The Journal of infectious diseases, Vol. 178, Issue 4, pp. 1193-7, (1998) (PubMed).
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- 抗原
- HCV E2 (Hepatitis C Virus Envelope Protein E2 (HCV E2))
- 别名
- E2 (HCV E2 产品)
- 物质类
- Viral Protein
- 背景
- Envelope glycoproteins E1 and E2 are involved in virus attachment to the host cell as well as in virus endocytosis and fusion with host membrane. E2 inhibits human EIF2AK2/PKR activation, preventing the establishment of an antiviral state. E2 is a viral ligand for CD209/DC-SIGN and CLEC4M/DCSIGNR, which are respectively found on dendritic cells (DCs), and on liver sinusoidal endothelial cells and macrophage-like cells of lymph node sinuses. These interactions allow capture of circulating HCV particles by these cells and subsequent transmission to permissive cells. DCs are professional antigen presenting cells, critical for host immunity by inducing specific immune responses against a broad variety of pathogens. They act as sentinels in various tissues where they entrap pathogens and convey them to local lymphoid tissue or lymph node for establishment of immunity. Capture of circulating HCV particles by these SIGN+ cells may facilitate virus infection of proximal hepatocytes and lymphocyte subpopulations and may be essential for the establishment of persistent infection.
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