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PTGS2 抗体 (N-Term)

PTGS2 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN965923
发货至: 中国
  • 抗原 See all PTGS2 抗体
    PTGS2 (Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2))
    抗原表位
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    N-Term
    适用
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    宿主
    • 95
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    克隆类型
    • 89
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    多克隆
    标记
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    This PTGS2 antibody is un-conjugated
    应用范围
    • 102
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    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    交叉反应
    小鼠, 大鼠
    交叉反应 (详细)
    No cross reactivity with other proteins.
    产品特性
    Rabbit IgG polyclonal antibody for Prostaglandin G/H synthase 2 (PTGS2) detection. Tested with WB, IHC-P in Human, Mouse, Rat.
    免疫原
    A synthetic peptide corresponding to a sequence at the N-terminal of human COX-2, different from the related rat sequence by two amino acids.< br/>Immunogen was affinity purified.
    亚型
    IgG
    Top Product
    Discover our top product PTGS2 Primary Antibody
  • 限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
    缓冲液
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    储存液
    Sodium azide, Thimerosal (Merthiolate)
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    -20 °C
    储存方法
    At -20 °C for one year. After reconstitution, at 4 °C for one month. It can also be aliquotted and stored frozen at -20 °C for a longer time.
  • Wilkinson-Berka, Alousis, Kelly, Gilbert: "COX-2 inhibition and retinal angiogenesis in a mouse model of retinopathy of prematurity." in: Investigative ophthalmology & visual science, Vol. 44, Issue 3, pp. 974-9, (2003) (PubMed).

    Brewer, Khor, Vogt, Muglia, Fujiwara, Haegele, Sleckman, Muglia: "T-cell glucocorticoid receptor is required to suppress COX-2-mediated lethal immune activation." in: Nature medicine, Vol. 9, Issue 10, pp. 1318-22, (2003) (PubMed).

    Liu, Chang, Narko, Trifan, Wu, Smith, Haudenschild, Lane, Hla: "Overexpression of cyclooxygenase-2 is sufficient to induce tumorigenesis in transgenic mice." in: The Journal of biological chemistry, Vol. 276, Issue 21, pp. 18563-9, (2001) (PubMed).

  • 抗原
    PTGS2 (Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2))
    别名
    Prostaglandin G/H synthase 2 (PTGS2 产品)
    别名
    COX-2 antibody, COX2 antibody, GRIPGHS antibody, PGG/HS antibody, PGHS-2 antibody, PHS-2 antibody, hCox-2 antibody, Cox-2 antibody, Pghs2 antibody, TIS10 antibody, Cox2 antibody, cox-2 antibody, CEF147 antibody, PGHS2 antibody, PHSII antibody, cox2 antibody, gripghs antibody, pgg/hs antibody, pghs-2 antibody, phs-2 antibody, PTGS2 antibody, hcox-2 antibody, fj02a10 antibody, ptgs2 antibody, unp1239 antibody, wu:fj02a10 antibody, zCOX-2 antibody, si:dkey-97o5.6 antibody, prostaglandin-endoperoxide synthase 2 antibody, prostaglandin G/H synthase 2 antibody, prostaglandin-endoperoxide synthase 2S homeolog antibody, prostaglandin-endoperoxide synthase 2a antibody, prostaglandin-endoperoxide synthase 2b antibody, PTGS2 antibody, Ptgs2 antibody, LOC100136456 antibody, ptgs2.S antibody, ptgs2 antibody, ptgs2a antibody, ptgs2b antibody
    背景
    Cyclooxygenase (Cox) is the key enzyme in conversion of arachidonic acid to PGs, and two isoforms, Cox-1 and Cox-2, have been identified. Cox-2 gene encodes an inducible prostaglandin synthase enzyme that is overexpressed in adenocarcinomas and other tumors. Deletion of the murine Cox-2 gene in Min mice reduced the incidence of intestinal tumors, suggesting that it is required for tumorigenesis. This gene is localized to sites associated with retinal blood vessels, and plays an important role in blood vessel formation in the retina. And the glucocorticoid receptor suppression of COX-2 is also crucial for curtailing lethal immune activation, and suggest new therapeutic approaches for regulation of T-cell-mediated inflammatory diseases.
    途径
    Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation
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