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KRT17 抗体

KRT17 适用: 人 WB, IHC, ELISA 宿主: 小鼠 Monoclonal 3B12 unconjugated
产品编号 ABIN965900
发货至: 中国
  • 抗原 See all KRT17 抗体
    KRT17 (Keratin 17 (KRT17))
    适用
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    宿主
    • 100
    • 35
    小鼠
    克隆类型
    • 87
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    单克隆
    标记
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    This KRT17 antibody is un-conjugated
    应用范围
    • 103
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    Western Blotting (WB), Immunohistochemistry (IHC), ELISA
    纯化方法
    Ascitic fluid
    免疫原
    Purified recombinant fragment of CK17 expressed in E. Coli.
    克隆位点
    3B12
    亚型
    IgG2b
    Top Product
    Discover our top product KRT17 Primary Antibody
  • 应用备注
    Western Bloting: 1/500 - 1/2000.
    Immunohistochemistry: 1/200 - 1/1000.
    ELISA: Propose dilution 1/10000.
    Not yet tested in other applications.
    Determining optimal working dilutions by titration test.
    限制
    仅限研究用
  • 状态
    Liquid
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
  • van de Rijn, Perou, Tibshirani, Haas, Kallioniemi, Kononen, Torhorst, Sauter, Zuber, Köchli, Mross, Dieterich, Seitz, Ross, Botstein, Brown: "Expression of cytokeratins 17 and 5 identifies a group of breast carcinomas with poor clinical outcome." in: The American journal of pathology, Vol. 161, Issue 6, pp. 1991-6, (2002) (PubMed).

    Leigh, Navsaria, Purkis, McKay, Bowden, Riddle: "Keratins (K16 and K17) as markers of keratinocyte hyperproliferation in psoriasis in vivo and in vitro." in: The British journal of dermatology, Vol. 133, Issue 4, pp. 501-11, (1995) (PubMed).

  • 抗原
    KRT17 (Keratin 17 (KRT17))
    别名
    CK17 (KRT17 产品)
    别名
    K17 antibody, Krt1-17 antibody, PC antibody, PC2 antibody, PCHC1 antibody, Ka17 antibody, KRT17 antibody, krt16 antibody, si:dkeyp-113d7.7 antibody, KRT14 antibody, keratin 17 antibody, keratin 17 L homeolog antibody, keratin 17, type I antibody, keratin, type I cytoskeletal 17 antibody, Krt17 antibody, KRT17 antibody, krt17 antibody, krt17.L antibody, LOC100737113 antibody, LOC102177275 antibody
    背景
    CK17, also known as KRT17, it is the type I intermediate filament chain keratin 17. It is found in nail beds, hair follicles, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial stem cells. May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair.
    Synonyms: PC, K17, PC2, PCHC1, KRT17
    分子量
    49kDa
    基因ID
    3872
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