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CD80 抗体 (N-Term)

CD80 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN965820
发货至: 中国
  • 抗原 See all CD80 抗体
    CD80
    抗原表位
    • 16
    • 15
    • 12
    • 10
    • 8
    • 6
    • 6
    • 4
    • 4
    • 4
    • 3
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    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 57-71, N-Term
    适用
    • 132
    • 110
    • 43
    • 6
    • 3
    • 3
    • 1
    • 1
    • 1
    宿主
    • 88
    • 63
    • 24
    • 21
    • 15
    • 1
    • 1
    克隆类型
    • 133
    • 77
    • 2
    多克隆
    标记
    • 87
    • 18
    • 17
    • 16
    • 13
    • 6
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CD80 antibody is un-conjugated
    应用范围
    • 127
    • 92
    • 68
    • 37
    • 29
    • 19
    • 14
    • 13
    • 13
    • 13
    • 12
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    • 4
    • 2
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    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    免疫原
    A synthetic peptide corresponding to a sequence at the N-terminal of human CD80 (57-71aa), identical to the related mouse and rat sequence.
    Top Product
    Discover our top product CD80 Primary Antibody
  • 应用备注
    WB: The detection limit for CD80/ B7-1 is approximately 2.5ng/lane under non-reducing and reducing conditions.
    限制
    仅限研究用
  • 溶解方式
    0.2ml of distilled water will yield a concentration of 500µg/ml.
    缓冲液
    Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4
    储存液
    Thimerosal (Merthiolate), Sodium azide
    储存条件
    -20 °C
  • Stamper, Zhang, Tobin, Erbe, Ikemizu, Davis, Stahl, Seehra, Somers, Mosyak: "Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses." in: Nature, Vol. 410, Issue 6828, pp. 608-11, (2001) (PubMed).

    Peach, Bajorath, Naemura, Leytze, Greene, Aruffo, Linsley: "Both extracellular immunoglobin-like domains of CD80 contain residues critical for binding T cell surface receptors CTLA-4 and CD28." in: The Journal of biological chemistry, Vol. 270, Issue 36, pp. 21181-7, (1995) (PubMed).

  • 抗原
    CD80
    别名
    CD80 (CD80 产品)
    别名
    B7 antibody, B7-1 antibody, B7.1 antibody, BB1 antibody, CD28LG antibody, CD28LG1 antibody, LAB7 antibody, B71 antibody, Cd28l antibody, Ly-53 antibody, Ly53 antibody, MIC17 antibody, TSA1 antibody, CD80 molecule antibody, Cd80 molecule antibody, CD80 antigen antibody, CD80 antibody, Cd80 antibody
    背景
    Cluster of Differentiation 80 (also CD80 and B7-1) is a protein found on activated B cells and monocytes that provides a costimulatory signal necessary for T cell activation and survival. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD80 works in tandem with CD86 to prime T cells. The CD80 genes encode B7-1 which are structurally similar members of the immunoglobulin superfamily expressed on a variety of hematopoietic cell types. Reeves et al. (1997) stated that B7-1 and B7-2 provide a costimulatory signal to T cells by interacting with CD28 and CTLA4.
    途径
    TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints
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