BRIP1 抗体 (C-Term)
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北京 101111
Quick Overview for BRIP1 抗体 (C-Term) (ABIN965699)
抗原
See all BRIP1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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免疫原
- Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human BRIP1(ATP-dependent RNA helicase)
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anti-BRCA1 Interacting Protein C-terminal Helicase 1 (BRIP1) (AA 904-986) antibody
BRIP1 适用: 人 ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 1B8F9 unconjugated
anti-BRCA1 Interacting Protein C-terminal Helicase 1 (BRIP1) (pSer990) antibodyBRIP1 适用: 人, 小鼠 WB, ELISA, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-BRCA1 Interacting Protein C-terminal Helicase 1 (BRIP1) (N-Term) antibodyBRIP1 适用: 人 WB, IHC (p), IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-BRCA1 Interacting Protein C-terminal Helicase 1 (BRIP1) antibodyBRIP1 适用: 人, 小鼠, 大鼠, 小鸡, Cow, 犬, 马, Pig WB, IF (p), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-BRCA1 Interacting Protein C-terminal Helicase 1 (BRIP1) (AA 66-243) antibodyBRIP1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-BRCA1 Interacting Protein C-terminal Helicase 1 (BRIP1) (AA 1-260) antibodyBRIP1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-BRCA1 Interacting Protein C-terminal Helicase 1 (BRIP1) antibodyBRIP1 适用: 人 WB 宿主: 兔 Monoclonal 23GB4360 unconjugated Recombinant Antibody
anti-BRCA1 Interacting Protein C-terminal Helicase 1 (BRIP1) (AA 135-167), (N-Term) antibodyBRIP1 适用: 人, 小鼠 WB, EIA 宿主: 兔 Polyclonal unconjugated
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限制
- 仅限研究用
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储存条件
- 4 °C
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: "The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 8, pp. 2357-62, (2004) (PubMed).
: "The BRCT domain is a phospho-protein binding domain." in: Science (New York, N.Y.), Vol. 302, Issue 5645, pp. 639-42, (2003) (PubMed).
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- BRIP1 (BRCA1 Interacting Protein C-terminal Helicase 1 (BRIP1))
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别名
- BRIP1
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背景
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BRIP1(ATP-dependent RNA helicase Is a DNA-dependent ATPase and 5' to 3' DNA helicase which is required for the maintenance of chromosomal stability. BRIP1 acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. BRIP1 is involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1. BRIP1 binds directly to the BRCT domains of BRCA1. BRIP1 is ubiquitously expressed, with highest levels in testis. Defects in BRIP1 are a cause of susceptibility to breast cancer (BC). BC is an extremely common malignancy, affecting one in eight women during their lifetime. A positive family history has been identified as major contributor to risk of development of the disease, and this link is striking for early-onset breast cancer. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage), and defective DNA repair.
Synonyms: FACJ (Fanconi anemia group J protein), BRCA1(interacting protein C-terminal helicase 1) -
途径
- DNA Damage Repair
抗原
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