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BCAR1 抗体 (C-Term)

BCAR1 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN965641
发货至: 中国
  • 抗原 See all BCAR1 抗体
    BCAR1 (Breast Cancer Anti-Estrogen Resistance 1 (BCAR1))
    抗原表位
    • 28
    • 21
    • 15
    • 7
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    C-Term
    适用
    • 108
    • 60
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    • 4
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    人, 小鼠, 大鼠
    宿主
    • 116
    • 8
    • 2
    • 1
    克隆类型
    • 121
    • 6
    多克隆
    标记
    • 60
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    This BCAR1 antibody is un-conjugated
    应用范围
    • 54
    • 40
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    • 24
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    • 12
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    Immunohistochemistry (IHC)
    免疫原
    Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human BCAR1 (Breast cancer anti-estrogen resistance protein 1)
    Top Product
    Discover our top product BCAR1 Primary Antibody
  • 限制
    仅限研究用
  • 储存条件
    4 °C
  • Beausoleil, Villén, Gerber, Rush, Gygi: "A probability-based approach for high-throughput protein phosphorylation analysis and site localization." in: Nature biotechnology, Vol. 24, Issue 10, pp. 1285-92, (2006) (PubMed).

    Prasad, Topping, Decker: "SH2-containing inositol 5'-phosphatase SHIP2 associates with the p130(Cas) adapter protein and regulates cellular adhesion and spreading." in: Molecular and cellular biology, Vol. 21, Issue 4, pp. 1416-28, (2001) (PubMed).

    Eisenmann, McCarthy, Simpson, Keely, Guan, Tachibana, Lim, Manser, Furcht, Iida: "Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas." in: Nature cell biology, Vol. 1, Issue 8, pp. 507-13, (2000) (PubMed).

  • 抗原
    BCAR1 (Breast Cancer Anti-Estrogen Resistance 1 (BCAR1))
    别名
    BCAR1 (BCAR1 产品)
    别名
    CAS antibody, CAS1 antibody, CASS1 antibody, CRKAS antibody, P130Cas antibody, AI385681 antibody, Cas antibody, Crkas antibody, P130CAS antibody, MGC68466 antibody, cas antibody, p130cas antibody, BCAR1 antibody, fc17f11 antibody, wu:fc17f11 antibody, zgc:175192 antibody, BCAR1, Cas family scaffolding protein antibody, breast cancer anti-estrogen resistance 1 antibody, breast cancer anti-estrogen resistance 1 L homeolog antibody, breast cancer anti-estrogen resistance protein 1 antibody, BCAR1 antibody, Bcar1 antibody, bcar1.L antibody, bcar1 antibody, LOC100435586 antibody
    背景
    BCAR1 (Breast cancer anti-estrogen resistance protein 1) is a docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. BCAR1 is implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells. BCAR1 forms complexes in vivo with focal adhesion kinase 1, adapter protein CRKL and LYN kinase. BCAR1 can heterodimerize with CASL. BCAR1 interacts with BCAR3, NPHP1, PTK2B and SH2D3C and interacts with activated CSPG4 as well as interacts with INPPL1/SHIP2. BCAR1 localizes in cell junction, focal adhesion, cytoplasm. The unphosphorylated form localizes in the cytoplasm and can move to the membrane upon tyrosine phosphorylation. BCAR1 is widely expressed with an abundant expression in the testis. Low level of expression seen in the liver, thymus, and peripheral blood leukocytes. The protein has been detected in a B-cell line. BCAR1 contains a central domain (substrate domain) containing multiple potential SH2-binding sites and a C-terminal domain containing a divergent helix-loop-helix (HLH) motif. The SH2-binding sites putatively bind CRK, NCK and ABL SH2 domains. The HLH motif is absolutely required for the induction of pseudohyphal growth in yeast and mediates heterodimerization with CASL. A serine-rich region promotes activation of the serum response element (SRE). The SH3 domain is necessary for the localization of the protein to focal adhesions and interacts with one proline-rich region of focal adhesion kinase 1. Focal adhesion kinase 1 phosphorylates the protein at the YDYVHL motif. SRC-family kinases are recruited to the phosphorylated sites and can phosphorylate other tyrosine residues. Tyrosine phosphorylation is triggered by integrin mediated adhesion of cells to the extracellular matrix.
    Synonyms: CAS, CASS1 (Cas scaffolding protein family member 1), CRKAS (CRK-associated substrate, p130cas),
    途径
    EGFR Signaling Pathway, Neurotrophin Signaling Pathway, CXCR4-mediated Signaling Events, Platelet-derived growth Factor Receptor Signaling
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