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Apoa5(ab) 抗体

适用: 人 ELISA, WB Monoclonal unconjugated
产品编号 ABIN965571
发货至: 中国
  • 抗原
    Apoa5(ab)
    适用
    宿主
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    克隆类型
    • 1
    单克隆
    标记
    • 1
    非结合性
    应用范围
    ELISA, Western Blotting (WB)
    特异性
    Ni-NTA purified truncated recombinant human APOA5 expressed in E. Coli strain BL21 (DE3)
    纯化方法
    Crude ascites.
    亚型
    IgG1
  • 应用备注
    Dilution: Western Blot: 1:500-1,000
    ELISA: Determining optimal working dilutions by titration test.
    限制
    仅限研究用
  • 储存条件
    -20 °C
  • 抗原
    Apoa5(ab)
    背景
    Apolipoprotein A5 (ApoA5) is fast gaining attention as a key regulator of serum triglyceride concentrations. An ApoA5 mouse knock-out model produced an approximately four fold increase in serum triglycerides, whereas a knock-in model with human ApoA5 produced 50-70% lower concentrations of mouse serum triglycerides. In addition, peroxisome proliferator-activated receptor-_ agonists, which are used clinically to lower serum triglyceride concentrations, cause increased ApoA5 mRNA expression. Recently, it was demonstrated that ApoA5 is present in human serum detected by polyclonal antibodies against both the NH2 and COOH termini, although at much lower concentration than other apolipoproteins.
    基因ID
    116519
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