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PF4 抗体

PF4 适用: 人 WB, EIA 宿主: 小鼠 Monoclonal KKO unconjugated
产品编号 ABIN954177
发货至: 中国
  • 抗原 See all PF4 抗体
    PF4 (Platelet Factor 4 (PF4))
    适用
    • 66
    • 14
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    宿主
    • 66
    • 18
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    • 1
    • 1
    小鼠
    克隆类型
    • 69
    • 20
    单克隆
    标记
    • 45
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    • 1
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    This PF4 antibody is un-conjugated
    应用范围
    • 65
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    Western Blotting (WB), Enzyme Immunoassay (EIA)
    特异性
    This antibody is specific for Human Platelet Factor IV/heparin complexes. AM31851PU-N (clone KKO), unlike AM31850PU-N (clone RTO) which binds PF4 alone, is specific for PF4/heparin complexes and is seen to have similar binding properties as auto-antibodies found in HIT/HITT.
    交叉反应 (详细)
    Species reactivity (tested):Human.
    纯化方法
    Protein G Chromatography of Ascitic fluid
    免疫原
    Human Factor IV purified from the supernatant of Thrombin activated platelets.
    克隆位点
    KKO
    亚型
    IgG2b
    Top Product
    Discover our top product PF4 Primary Antibody
  • 应用备注
    ELISA: Use at 0.08 μg/mL following coating plate with PF4/ heparin complex. This can be done by incubating PF4 with an excess of heparin (100-200 U/mL), while coating the plate.
    限制
    仅限研究用
  • 浓度
    1.0 mg/mL
    缓冲液
    PBS, 0.02 % Sodium Azide
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • 抗原
    PF4 (Platelet Factor 4 (PF4))
    别名
    Platelet Factor 4 / PF4 (PF4 产品)
    别名
    CXCL4 antibody, PF-4 antibody, SCYB4 antibody, Cxcl4 antibody, Scyb4 antibody, Pf4a antibody, RATPF4A antibody, PF4A antibody, CXCL4L1 antibody, CXCL4V1 antibody, PF4-ALT antibody, SCYB4V1 antibody, PF4 antibody, platelet factor 4 antibody, platelet factor 4 variant 1 antibody, PF4 antibody, Pf4 antibody, LOC703451 antibody, PF4V1 antibody, LOC100524373 antibody, LOC102181854 antibody, LOC100630489 antibody
    背景
    Platelet Factor IV (PF4) is a 70 aa protein released from the alpha granules of activated platelets. PF4 is synthesized by bone marrow megakaryocytes and stored in alpha granules as a non-covalent bound tetramer. Platelet factor IV binds with high affinity to heparin and plays a role in inflammation and wound repair. PF4 is a chemoattractant for neutrophils, monocytes and fibroblasts and has been reported to be an immunologic regulator that inhibits suppressor T-cell activity. Heparin-Induced Thrombocytopenia/Thrombosis (HIT/HITT) is a life-threatening complication that manifests itself in a small population of patients exposed to intravenous-heparin. It is characterized by the production of PF4/heparin auto-antibodies. These auto-antibodies bind the PF4/heparin complexes and subsequently bind the FCGIIa receptor on the platelets surface through their Fc region. This activates the platelets and can initiate clot formation.Synonyms: C-X-C motif chemokine 4, CXCL4, Iroplact, Oncostatin-A, PF-4, SCYB4
    基因ID
    5196
    NCBI登录号
    NP_002610
    UniProt
    P02776
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