mxi antibody, mad2 antibody, mxd2 antibody, xmxi1 antibody, MGC89544 antibody, MXI1 antibody, etID309773.22 antibody, fb16b12 antibody, fb55f03 antibody, wu:fb16b12 antibody, wu:fb55f03 antibody, wu:fd06a08 antibody, wu:fz74f10 antibody, ENSMUSG00000067085 antibody, Gm10197 antibody, Mad2 antibody, bHLHc11 antibody, MXI-WR antibody, MAD2 antibody, MXD2 antibody, MXI antibody, MAX interactor 1, dimerization protein antibody, max interactor 1, dimerization protein antibody, MAX interactor 1, dimerization protein L homeolog antibody, mxi1 antibody, MXI1 antibody, Mxi1 antibody, mxi1.L antibody
背景
Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally.Synonyms: Class C basic helix-loop-helix protein 11, MAX-interacting protein 1, Max interactor 1, bHLHc11