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LIN28A 抗体

LIN28A 适用: 人, 小鼠 WB, FACS, EIA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN953173
发货至: 中国
  • 抗原 See all LIN28A 抗体
    LIN28A (Lin-28 Homolog A (C. Elegans) (LIN28A))
    适用
    • 102
    • 29
    • 21
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    人, 小鼠
    宿主
    • 82
    • 22
    克隆类型
    • 75
    • 29
    多克隆
    标记
    • 49
    • 9
    • 7
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    This LIN28A antibody is un-conjugated
    应用范围
    • 69
    • 41
    • 30
    • 22
    • 16
    • 14
    • 14
    • 13
    • 9
    • 9
    • 7
    • 3
    • 3
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Enzyme Immunoassay (EIA)
    特异性
    This antibody recognizes Human and Mouse LIN28.
    纯化方法
    Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
    免疫原
    His fusion protein from Human LIN28A
    亚型
    Ig Fraction
    Top Product
    Discover our top product LIN28A Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    0.25 mg/mL
    缓冲液
    PBS containing 0.09 % (W/V) Sodium Azide as preservative
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • 抗原
    LIN28A (Lin-28 Homolog A (C. Elegans) (LIN28A))
    别名
    LIN28 (LIN28A 产品)
    别名
    CSDD1 antibody, LIN-28 antibody, LIN28 antibody, ZCCHC1 antibody, lin-28A antibody, AL024421 antibody, ENSMUSG00000070700 antibody, Gm10299 antibody, Lin-28 antibody, Lin28 antibody, Tex17 antibody, csdd1 antibody, lin-28 antibody, lin28 antibody, zcchc1 antibody, sb:cb650 antibody, zgc:55584 antibody, RGD1566408 antibody, lin-28 homolog A antibody, lin-28 homolog A (C. elegans) antibody, lin-28 homolog A S homeolog antibody, LIN28A antibody, Lin28a antibody, lin28a.S antibody, lin28a antibody
    背景
    Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression (By similarity). Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 in embryonic stem (ES) cells contributes to the maintenance of ES cells. In contrast, LIN28A down-regulation in neural stem cells by miR-125, allows the processing of pre-let-7. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation.Synonyms: CSDD1, LIN-28, LIN28A, Lin-28 homolog A, ZCCHC1
    分子量
    22743 Da
    基因ID
    79727
    NCBI登录号
    NP_078950
    途径
    Stem Cell Maintenance
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