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C6orf150 抗体 (Middle Region)

C6orf150 适用: 人 WB, EIA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN950947
发货至: 中国
  • 抗原 See all C6orf150 抗体
    C6orf150 (Chromosome 6 Open Reading Frame 150 (C6orf150))
    抗原表位
    • 7
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 273-303, Middle Region
    适用
    • 29
    • 7
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    宿主
    • 32
    • 1
    克隆类型
    • 32
    • 1
    多克隆
    标记
    • 16
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This C6orf150 antibody is un-conjugated
    应用范围
    • 27
    • 17
    • 7
    • 7
    • 6
    • 2
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    特异性
    This antibody recognizes Human C6orf150 (CF150). Other species not tested.
    纯化方法
    Affinity chromatography on Protein A
    免疫原
    KLH conjugated synthetic peptide between 273-303 amino acids from the Central region of human CF150
    亚型
    Ig Fraction
    Top Product
    Discover our top product C6orf150 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    0.25 mg/mL
    缓冲液
    PBS, 0.09 % (W/V) Sodium Azide
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • 抗原
    C6orf150 (Chromosome 6 Open Reading Frame 150 (C6orf150))
    别名
    C6orf150 (C6orf150 产品)
    别名
    C6orf150 antibody, cGAS antibody, h-cGAS antibody, Mab-21 domain containing 1 antibody, cyclic GMP-AMP synthase antibody, MB21D1 antibody, CGAS antibody
    背景
    Function: Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double- stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production. Cellular Location: Cytoplasm, cytosol. Tissue Location: Expressed in the monocytic cell line THP1.Synonyms: Uncharacterized protein C6orf150
    分子量
    58814 Da
    基因ID
    115004
    NCBI登录号
    NP_612450
    途径
    Activation of Innate immune Response
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