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HLA-E 抗体

HLA-E 适用: 人, Non-Human Primate WB, IHC (p) 宿主: 小鼠 Monoclonal MEM-E-02 unconjugated
产品编号 ABIN94352
发货至: 中国
  • 抗原 See all HLA-E 抗体
    HLA-E (HLA Class I Histocompatibility Antigen, alpha Chain E (HLA-E))
    适用
    • 66
    • 3
    • 2
    • 2
    • 2
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    人, Non-Human Primate
    宿主
    • 44
    • 23
    小鼠
    克隆类型
    • 46
    • 21
    单克隆
    标记
    • 30
    • 6
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    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
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    This HLA-E antibody is un-conjugated
    应用范围
    • 41
    • 27
    • 19
    • 13
    • 13
    • 11
    • 9
    • 7
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    特异性
    The antibody MEM-E/02 specifically reacts with an extracellular epitope on denaturated heavy chain of human HLA-E. HLA-E belongs to the MHC Class I molecules (MHC Class Ib, nonclassical) and it is expressed on the surface of all human cell types.
    交叉反应 (详细)
    Human, Non-Human Primates
    纯化方法
    Purified by protein-A affinity chromatography.
    纯度
    > 95 % (by SDS-PAGE)
    免疫原
    Recombinant human HLA-E denaturated heavy chain.
    克隆位点
    MEM-E-02
    亚型
    IgG1
    Top Product
    Discover our top product HLA-E Primary Antibody
  • 应用备注
    Immunohistochemistry (paraffin sections): Recommended dilution: 5-10 μg/mL, positive control: human placenta, heat antigen retrieval (sodium citrate), incubation with mAb: 1 hour / RT, detection DAB.
    限制
    仅限研究用
  • 浓度
    1 mg/mL
    缓冲液
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Do not freeze.
    储存条件
    4 °C
    储存方法
    Store at 2-8°C. Do not freeze.
  • Platonova, Cherfils-Vicini, Damotte, Crozet, Vieillard, Validire, André, Dieu-Nosjean, Alifano, Régnard, Fridman, Sautès-Fridman, Cremer: "Profound coordinated alterations of intratumoral NK cell phenotype and function in lung carcinoma." in: Cancer research, Vol. 71, Issue 16, pp. 5412-22, (2011) (PubMed).

    Lo Monaco, Tremante, Cerboni, Melucci, Sibilio, Zingoni, Nicotra, Natali, Giacomini: "Human leukocyte antigen E contributes to protect tumor cells from lysis by natural killer cells." in: Neoplasia (New York, N.Y.), Vol. 13, Issue 9, pp. 822-30, (2011) (PubMed).

    Dambaeva, Bondarenko, Grendell, Kravitz, Durning, Golos: "Non-classical MHC-E (Mamu-E) expression in the rhesus monkey placenta." in: Placenta, Vol. 29, Issue 1, pp. 58-70, (2008) (PubMed).

    Menier, Saez, Horejsi, Martinozzi, Krawice-Radanne, Bruel, Le Danff, Reboul, Hilgert, Rabreau, Larrad, Pla, Carosella, Rouas-Freiss: "Characterization of monoclonal antibodies recognizing HLA-G or HLA-E: new tools to analyze the expression of nonclassical HLA class I molecules." in: Human immunology, Vol. 64, Issue 3, pp. 315-26, (2003) (PubMed).

  • 抗原
    HLA-E (HLA Class I Histocompatibility Antigen, alpha Chain E (HLA-E))
    别名
    HLA-E (HLA-E 产品)
    别名
    EA1.2 antibody, EA2.1 antibody, HLA-6.2 antibody, MHC antibody, QA1 antibody, major histocompatibility complex, class I, E antibody, HLA-E antibody, PATR-E antibody
    背景
    Major histocompatibility complex, class I, E,HLA-E (human leukocyte antigen E) is a non-classical MHC I antigen, which is important for dialogue with NK cells and their regulation through interaction with CD94/NKG2 receptor. Like other MHC I molecules, transmembrane HLA-E molecule (45 kDa) associates with beta2 microglobulin. Unlike HLA-G, expression of HLA-E molecules is not so restricted, but it has been detected at least at mRNA level in virtually all cells and tissues examined. In peripheral blood, HLA-E protein is expressed at least in all mononuclear cells, but in different quantity (B cells and monocytes more than T cells and NK cells).,HLA class I histocompatibility antigen, alpha chain E, MHC class I antigen E
    基因ID
    3133
    UniProt
    P13747
    途径
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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