TARDBP 抗体 (C-Term, Cleavage Site)
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- 抗原 See all TARDBP 抗体
- TARDBP (TAR DNA Binding Protein (TARDBP))
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抗原表位
- C-Term, Cleavage Site
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适用
- 人, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This TARDBP antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 特异性
- Specific for the ~ 43 kDa TDP-43 protein in Western blots of Rat brain lysate. Expected molecular weight is dependent upon the TDP-43 species present in sample (full-length vs. truncated TDP-43). Under non-denaturing conditions (for example, by IHC), this antibody detects TDP-43 inclusions in Human brain tissue with TDP-43 proteinopathy, but does not detect full-length nuclear TDP-43. Under denaturing conditions (for example, by Western Blot analysis) this antibody detects the C-terminus of full-length and truncated Human TDP-43.
- 交叉反应 （详细）
- Species reactivity (tested):Human and Rat.
- 纯化方法
- Affinity Chromatography.
- 免疫原
- Synthetic peptide C-terminal to the caspase-cleavage site (between D219 and V220) of Human TDP-43.
- 亚型
- IgG
- Top Product
- Discover our top product TARDBP Primary Antibody
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anti-TAR DNA Binding Protein (TARDBP) (AA 1-260) antibody
TARDBP 适用: 人 WB, ELISA, IF, IP, IHC (p), RNAi 宿主: 小鼠 Monoclonal 2E2-D3 unconjugated
anti-TAR DNA Binding Protein (TARDBP) (AA 104-262) antibodyTARDBP 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-TAR DNA Binding Protein (TARDBP) (AA 1-260) antibodyTARDBP 适用: 人 WB, IP, RIP 宿主: 兔 Polyclonal unconjugated
anti-TAR DNA Binding Protein (TARDBP) (C-Term) antibodyTARDBP 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-TAR DNA Binding Protein (TARDBP) (AA 1-100) antibodyTARDBP 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-TAR DNA Binding Protein (TARDBP) antibodyKO Validated TARDBP 适用: 人 WB, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-TAR DNA Binding Protein (TARDBP) (N-Term) antibodyTARDBP 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-TAR DNA Binding Protein (TARDBP) (AA 1-396) antibodyTARDBP 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-TAR DNA Binding Protein (TARDBP) antibodyTARDBP 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-TAR DNA Binding Protein (TARDBP) (AA 1-261) antibodyTARDBP 适用: 人 WB, IHC, ELISA, IF, IHC (p), RNAi 宿主: 小鼠 Monoclonal 2E2-D3 unconjugated
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS containing 30 % Glycerol.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- -80 °C
- 储存方法
- Store the antibody undiluted (in aliquots) at -80 °C.
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- 抗原
- TARDBP (TAR DNA Binding Protein (TARDBP))
- 别名
- TARDBP (TARDBP 产品)
- 别名
- TARDBP antibody, TDP43 antibody, DKFZp459I2127 antibody, tardbp antibody, ALS10 antibody, TDP-43 antibody, 1190002A23Rik antibody, C85084 antibody, Tdp43 antibody, wu:fb77f02 antibody, wu:fc52g10 antibody, TAR DNA binding protein antibody, Tardbp protein antibody, TAR DNA binding protein L homeolog antibody, TAR DNA-binding protein 43-like antibody, TARDBP antibody, tardbp antibody, tardbp.L antibody, Tardbp antibody, LOC100621383 antibody
- 背景
- TDP43 (Tar DNA Binding 43, TARDBP) was originally identified as a protein which binds to the "transactivation response" (TAR) sequence found in the long terminal repeat of the HIV-1 virus genome (Ou et al.,1995). UV cross-linking of HeLa cell extract revealed a 43 kDa protein which was cloned and sequenced and shown to contain two copies of the ~90 amino acid RRM domain. RRM is an acronym for RNA Recognition Motif, and this domain is found in many proteins which bind single stranded RNA and some which bind single stranded DNA. Northern blots showed that the protein is ubiquitous in tissue expression. Much interest has been focused on TDP43 recently due to its association with the inclusions seen in frontotemporal lobar degeneration and Amyotrophic Lateral Sclerosis (Neumann et al., 2006). The protein is present in these inclusions in partially degraded, hyperphosphorylated and ubiquitinated forms.Synonyms: TAR DNA-binding protein 43, TDP-43, TDP43
- 基因ID
- 23435
- NCBI登录号
- NP_031401
- 途径
- Positive Regulation of Peptide Hormone Secretion
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