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NLRP12 抗体 (N-Term)

NLRP12 适用: 人, 小鼠, 大鼠 WB, EIA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN783719
发货至: 中国
  • 抗原 See all NLRP12 抗体
    NLRP12 (NLR Family, Pyrin Domain Containing 12 (NLRP12))
    抗原表位
    • 15
    • 8
    • 8
    • 8
    • 7
    • 5
    • 2
    • 1
    • 1
    • 1
    N-Term
    适用
    • 50
    • 17
    • 14
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠
    宿主
    • 49
    • 3
    • 1
    克隆类型
    • 50
    • 3
    多克隆
    标记
    • 19
    • 5
    • 5
    • 5
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This NLRP12 antibody is un-conjugated
    应用范围
    • 36
    • 33
    • 14
    • 13
    • 13
    • 6
    • 4
    • 2
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    特异性
    This antibody detects NALP2 at N-term.
    交叉反应 (详细)
    Species reactivity (tested):Human, mouse, rat
    纯化方法
    Affinity chromatography purified via peptide column
    免疫原
    18 amino acid peptide near the amino terminus of human NALP12
    Top Product
    Discover our top product NLRP12 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 缓冲液
    PBS containing 0.02 % sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
  • 抗原
    NLRP12 (NLR Family, Pyrin Domain Containing 12 (NLRP12))
    别名
    NALP12 (NLRP12 产品)
    别名
    Nalp12 antibody, NALP12 antibody, CLR19.3 antibody, FCAS2 antibody, PAN6 antibody, PYPAF7 antibody, RNO antibody, RNO2 antibody, NLR family, pyrin domain containing 12 antibody, NLR family pyrin domain containing 12 antibody, NACHT, LRR and PYD domains-containing protein 3 antibody, Nlrp12 antibody, NLRP12 antibody, LOC100018508 antibody
    背景
    NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP12, also known as Monarch-1, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. NALP12 is thought to act as an attenuating factor of inflammation by suppressing inflammatory responses such as NF-kB activation by TLR-signaling molecules MyD88, IRAK-1, TRAF6 and RIPK1 in activated monocytes. Recent evidence suggests that mutations in NALP12 result in hereditary periodic fever syndromes.Synonyms: LRR and PYD domains-containing protein 12, Monarch-1, NACHT, NLRP12, PYPAF7, PYRIN-containing APAF1-like protein 7, RNO, Regulated by nitric oxide
    基因ID
    91662
    NCBI登录号
    NP_150639
    UniProt
    P59046
    途径
    Positive Regulation of Endopeptidase Activity, Inflammasome
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