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- 抗原 See all ATP2C2 抗体
- ATP2C2 (ATPase, Ca++ Transporting, Type 2C, Member 2 (ATP2C2))
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抗原表位
- N-Term
- 适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This ATP2C2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Enzyme Immunoassay (EIA)
- 特异性
- This antibody detects ATP2C2 at N-term. At least three isoforms of ATP2C2 are known to exist. ATP2C2 antibody will not cross-react with ATP2C1.
- 交叉反应 （详细）
- Species reactivity (tested):Human, mouse
- 纯化方法
- Affinity chromatography purified via peptide column
- 免疫原
- 19 amino acid peptide near the amino terminus of human ATP2C2
- Top Product
- Discover our top product ATP2C2 Primary Antibody
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anti-ATPase, Ca++ Transporting, Type 2C, Member 2 (ATP2C2) (AA 621-702) antibody
ATP2C2 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 缓冲液
- PBS containing 0.02 % sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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- 抗原
- ATP2C2 (ATPase, Ca++ Transporting, Type 2C, Member 2 (ATP2C2))
- 别名
- ATP2C2 (ATP2C2 产品)
- 别名
- KIAA0703 antibody, MGC146612 antibody, SPCA2 antibody, 1810010G06Rik antibody, Spca2 antibody, mKIAA0703 antibody, ATPase secretory pathway Ca2+ transporting 2 antibody, ATPase, Ca++ transporting, type 2C, member 2 S homeolog antibody, ATPase, Ca++ transporting, type 2C, member 2 antibody, ATP2C2 antibody, atp2c2.S antibody, atp2c2 antibody, Atp2c2 antibody
- 背景
- ATP2C2, also known as secretory pathway Ca2+/Mn2+-ATPase (SPCA) 2, belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium from the cytosol to the Golgi lumen. Defects in the related gene ATP2C1 cause Hailey-Hailey disease, for which ATP2C2 does not compensate, suggesting that ATP2C2 plays other physiological roles. Unlike ATP2C1, ATP2C2 has a much more restricted expression pattern and displays a higher maximal turnover rate for overall Ca2+-ATPase reaction and a lower apparent affinity for cytosolic Ca2+ activation of phosphorylation. Overexpression of ATP2C2 in mammary tumors result a Ca2+ influx via the store-operated Ca2+ channel ORAI1 and independent of the STIM1 and STIM2 sensors.Synonyms: ATP2C2, ATPase 2C2, Calcium-transporting ATPase type 2C member, EC=3.6.3.8, KIAA0703, SPCA2, Secretory pathway Ca(2+)-ATPase 2
- 基因ID
- 9914
- NCBI登录号
- NP_055676
- UniProt
- O75185
- 途径
- Ribonucleoside Biosynthetic Process
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