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SIRT1 抗体 (pSer47)

Name: SIRT1 抗体 (pSer47)
SKU: ABIN745658
Availability: OutOfStock

SIRT1 适用: 人, 小鼠, 大鼠, 犬 WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

Formalin-fixed and paraffin embedded human lung carcinoma labeled with Rabbit Anti-SIRT1(Ser47) Polyclonal Antibody, Unconjugated 1:200 followed by conjugation to the secondary antibody and DAB staining

IHC (p)

Formalin-fixed and paraffin embedded rat brain labeled with Anti-Phospho-SIRT1(Ser47) Polyclonal Antibody, Unconjugated (ABIN745658) at 1:200 followed by conjugation to the secondary antibody and DAB staining

IHC

2 images

(4 references)

产品编号 ABIN745658

发货至: 中国

Datasheet as PDF

抗原 See all SIRT1 抗体

SIRT1 (Sirtuin 1 (SIRT1))
抗原表位
26

16

16

9

8

7

6

6

5

4

3

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
pSer47
适用
141

87

56

33

5

3

2

2

2

2

2

1

1
人, 小鼠, 大鼠, 犬
宿主
127

20

2

2

1
兔
Compatible Secondaries
克隆类型
111

41
多克隆
标记
73

14

10

5

5

5

5

5

5

4

4

3

3

3

3

3

1

1
This SIRT1 antibody is un-conjugated
应用范围
124

49

49

40

38

35

26

23

19

14

8

4

4

4

2

1

1

1
Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

交叉反应

犬, 人, 小鼠, 大鼠

预测反应

Pig,Rabbit

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic phosphopeptide derived from human SirT1 around the phosphorylation site of Ser47

亚型

IgG

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SIRT1 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Sirtuin 1 (SIRT1) (AA 456-555) antibody
SIRT1 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 7B7 unconjugated

anti-Sirtuin 1 (SIRT1) (AA 448-747) antibody
SIRT1 适用: 人 WB, IHC, IP, IF 宿主: 兔 Polyclonal unconjugated

anti-Sirtuin 1 (SIRT1) (AA 566-601), (C-Term) antibody
SIRT1 适用: 人, 小鼠 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB50965 unconjugated

anti-Sirtuin 1 (SIRT1) antibody
SIRT1 适用: 人 WB, ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 1F3 unconjugated

anti-Sirtuin 1 (SIRT1) antibody
KO Validated SIRT1 适用: 人 WB, IHC, IP, IF, ChIP 宿主: 兔 Polyclonal unconjugated

anti-Sirtuin 1 (SIRT1) (N-Term) antibody
SIRT1 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, 兔, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated

anti-Sirtuin 1 (SIRT1) (AA 456-555) antibody
SIRT1 适用: 人 WB, IF, IHC (p), EIA 宿主: 小鼠 Monoclonal 7B7 unconjugated

anti-Sirtuin 1 (SIRT1) (AA 566-601) antibody
SIRT1 适用: 人, 小鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Sirtuin 1 (SIRT1) (AA 244-498) antibody
SIRT1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

应用备注

WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
Liu, Hou, Yuan, Hang, Zhao, Sun, Zhao, Zhao, Dong, Wang, Shi, Liu, Zhou, Dong, Liu, Zhan, Li, Li: "Fenofibrate inhibits atrial metabolic remodelling in atrial fibrillation through PPAR-α/sirtuin 1/PGC-1α pathway." in: British journal of pharmacology, Vol. 173, Issue 6, pp. 1095-109, (2016) (PubMed).

Suzuki, Bandoski, Bartlett: "Fluoride induces oxidative damage and SIRT1/autophagy through ROS-mediated JNK signaling." in: Free radical biology & medicine, Vol. 89, pp. 369-378, (2015) (PubMed).

Suzuki, Bartlett: "Sirtuin1 and autophagy protect cells from fluoride-induced cell stress." in: Biochimica et biophysica acta, Vol. 1842, Issue 2, pp. 245-55, (2014) (PubMed).
抗原

SIRT1 (Sirtuin 1 (SIRT1))

别名

SIRT1 (SIRT1 产品)

别名

sirtuin 1 antibody, AA673258 antibody, SIR2L1 antibody, Sir2 antibody, Sir2a antibody, Sir2alpha antibody, sir2l1 antibody, sirtuin antibody, SIR2 antibody, sirtuin 1 antibody, sirtuin 1 L homeolog antibody, SIRT1 antibody, SRT1 antibody, Sirt1 antibody, sirt1.L antibody

背景

Synonyms: SIR2L1, NAD-dependent protein deacetylase sirtuin-1, hSIRT1, Regulatory protein SIR2 homolog 1, SIR2-like protein 1, hSIR2, SIRT1
Background: This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined, however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.

基因ID

23411

UniProt

Q96EB6

途径

MAPK Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Carbohydrate Homeostasis, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus, Negative Regulation of intrinsic apoptotic Signaling