TRKA 抗体 (AA 725-821)
(1 reference)-
- 抗原 See all TRKA (NTRK1) 抗体
- TRKA (NTRK1) (Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1))
-
抗原表位
- AA 725-821
-
适用
- 人, 小鼠, 大鼠
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This TRKA antibody is un-conjugated
-
应用范围
- Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 交叉反应
- 人, 小鼠, 大鼠
- 预测反应
- Dog,Cow,Pig,Horse,Rabbit,Guinea Pig
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human NTRK1
- 亚型
- IgG
- Top Product
- Discover our top product NTRK1 Primary Antibody
-
anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (pTyr681), (Tyr680) antibody
NTRK1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (AA 33-208) antibodyNTRK1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) antibodyNTRK1 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (Extracellular Domain) antibodyNTRK1 适用: 人 WB, ELISA, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (C-Term) antibodyNTRK1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (AA 769-796) antibodyNTRK1 适用: 人 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) antibodyNTRK1 适用: 人, 小鼠 WB, ELISA, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (2nd Extracellular Domain), (AA 342-356) antibodyNTRK1 适用: 人, 小鼠, 大鼠 WB, IHC, IF, FACS, ICC, LCI 宿主: 兔 Polyclonal unconjugated
anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (pTyr496) antibodyNTRK1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (C-Term) antibodyNTRK1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
-
- 应用备注
-
WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - 限制
- 仅限研究用
-
- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- 有效期
- 12 months
-
-
: "Biological and clinical significance of p75NTR expression in laryngeal squamous epithelia and laryngocarcinoma." in: Acta oto-laryngologica, Vol. 132, Issue 3, pp. 314-24, (2012) (PubMed).
-
: "Biological and clinical significance of p75NTR expression in laryngeal squamous epithelia and laryngocarcinoma." in: Acta oto-laryngologica, Vol. 132, Issue 3, pp. 314-24, (2012) (PubMed).
-
- 抗原
- TRKA (NTRK1) (Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1))
- 别名
- TrkA (NTRK1 产品)
- 别名
- MTC antibody, TRK antibody, TRK1 antibody, TRKA antibody, Trk-A antibody, p140-TrkA antibody, CDHF12 antibody, CDHR16 antibody, HSCR1 antibody, MEN2A antibody, MEN2B antibody, MTC1 antibody, PTC antibody, RET-ELE1 antibody, RET51 antibody, Trk antibody, C80751 antibody, Tkr antibody, TrkA antibody, trk antibody, trka antibody, CTRKA antibody, trkA antibody, neurotrophic receptor tyrosine kinase 1 antibody, ret proto-oncogene antibody, neurotrophic tyrosine kinase, receptor, type 1 antibody, NTRK1 antibody, RET antibody, Ntrk1 antibody, ntrk1 antibody
- 背景
-
Synonyms: MTC, TRK, TRK1, TRKA, Trk-A, p14-TrkA, High affinity nerve growth factor receptor, Neurotrophic tyrosine kinase receptor type 1, TRK1-transforming tyrosine kinase protein, Tropomyosin-related kinase A, Tyrosine kinase receptor, Tyrosine kinase receptor A, gp14trk, NTRK1
Background: Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors. Isoform TrkA-III is resistant to NGF, constitutively activates AKT1 and NF-kappa-B and is unable to activate the Ras-MAPK signaling cascade. Antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes neuronal precursors differentiation. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed.
- 基因ID
- 4914
- UniProt
- P04629
- 途径
- RTK signaling, Neurotrophin Signaling Pathway, cAMP Metabolic Process
-
