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Caspase 3 抗体 (AA 60-100)

Name: Caspase 3 抗体 (AA 60-100)
SKU: ABIN724625
Availability: OutOfStock

CASP3 适用: 人, 小鼠, 大鼠, Cow, 山羊 WB, IF (cc) 宿主: 兔 Polyclonal unconjugated

Rat lung lysate 30ug, probed at 1:200 overnight in 4˚C.

Formalin-fixed and paraffin embedded Human oral squamous cell carcinoma labeled with Anti-Caspase-3 Polyclonal Antibody, Unconjugated (ABIN724625) at 1:200 followed by conjugation to the secondary antibody Goat Anti-Rabbit IgG, PE conjugated used at 1:200 dilution for 40 minutes at 37°C and DAPI staining

Human HepG2 cells probed with Rabbit Anti-Caspase 3 Polyclonal Antibody

FACS

Formalin-fixed and paraffin embedded rabbit pancreas tissue labeled with Anti-Caspase-3 Polyclonal Antibody, Unconjugated 1:300 followed by conjugation to the secondary antibody and DAB staining

IHC (p)

Image provided by One World Lab validation program.

IF (cc)

Neuronal apoptosis in acNTS of CRS mice.

IHC (p)

Erianin induced mitochondrial apoptosis in liver cancer cells.

7 images

(86 references)

产品编号 ABIN724625

发货至: 中国

Datasheet as PDF

抗原 See all Caspase 3 (CASP3) 抗体

Caspase 3 (CASP3)
抗原表位
19

16

16

16

16

16

15

15

14

13

12

11

10

9

8

7

7

6

6

6

5

5

4

4

3

3

3

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 60-100
适用
278

192

148

30

16

10

10

9

7

7

5

5

4

3

3

2

1

1

1
人, 小鼠, 大鼠, Cow, 山羊
宿主
279

40

4

2

2
兔
Compatible Secondaries
克隆类型
273

53
多克隆
标记
158

26

21

14

11

11

9

9

9

9

9

6

6

6

6

6

6

2

2

1
This Caspase 3 antibody is un-conjugated
应用范围
251

108

104

85

78

65

52

36

31

29

28

19

10

6

3

2

1

1

1

1
Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc))

交叉反应

小鸡, Cow, 人, 猴, 小鼠, Pig, 兔, 大鼠, 绵羊

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic peptide derived from human Caspase 3(Active)

亚型

IgG
anti-Caspase 3 (CASP3) (AA 67-175) antibody
CASP3 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Caspase 3 (CASP3) (AA 55-160) antibody
CASP3 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Caspase 3 (CASP3) (AA 220-236), (C-Term) antibody
CASP3 适用: 人 WB, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated

anti-Caspase 3 (CASP3) (AA 11-120) antibody
CASP3 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), FACS, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Caspase 3 (CASP3) antibody
CASP3 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 小鼠 Monoclonal 5E1 unconjugated

anti-Caspase 3 (CASP3) (cleaved) antibody
CASP3 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Caspase 3 (CASP3) (Internal Region) antibody
CASP3 适用: 人, 小鼠, 大鼠, Cow WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Caspase 3 (CASP3) (pSer150) antibody
CASP3 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Caspase 3 (CASP3) (AA 100-200) antibody
CASP3 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Caspase 3 (CASP3) (AA 29-175) antibody
CASP3 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

应用备注

WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
Zhang, Wang, Li, Yang, Li, Wang: "The anti-carcinogenesis properties of erianin in the modulation of oxidative stress-mediated apoptosis and immune response in liver cancer." in: Aging, Vol. 11, Issue 22, pp. 10284-10300, (2020) (PubMed).

Li, Li, Xi, Li, Ding, Li: "The effects of photobiomodulation therapy on mouse pre-osteoblast cell line MC3T3-E1 proliferation and apoptosis via miR-503/Wnt3a pathway." in: Lasers in medical science, Vol. 34, Issue 3, pp. 607-614, (2019) (PubMed).

Chu, Wang, Tang, Shi, Gao, Ma, Lu, Han, Jia, Wang, Adam, Liu, Xiao, Wang, Yang: "Newcastle Disease Virus V Protein Inhibits Cell Apoptosis and Promotes Viral Replication by Targeting CacyBP/SIP." in: Frontiers in cellular and infection microbiology, Vol. 8, pp. 304, (2019) (PubMed).

Chen, Wang, Chen, Zhang: "Conditional deletion of Bmp2 in cranial neural crest cells recapitulates Pierre Robin sequence in mice." in: Cell and tissue research, Vol. 376, Issue 2, pp. 199-210, (2019) (PubMed).

Zhang, Zhao, Zhang, Hao, Yu, Min, Li, Ma, Chen, Yi, Tang, Meng, Liu, Wang, Shen, Zhang: "Decrease in male mouse fertility by hydrogen sulfide and/or ammonia can Be inheritable." in: Chemosphere, Vol. 194, pp. 147-157, (2018) (PubMed).

Wang, Chu, Liu, Pang, Gao, Tang, Ma, Lu, Adam, Dang, Xiao, Wang, Yang: "Newcastle disease virus V protein inhibits apoptosis in DF-1 cells by downregulating TXNL1." in: Veterinary research, Vol. 49, Issue 1, pp. 102, (2018) (PubMed).

Zheng, Bi, Yang, Zhao, Wang, Li, Zhou: "Hyperglycemia Induced by Chronic Restraint Stress in Mice Is Associated With Nucleus Tractus Solitarius Injury and Not Just the Direct Effect of Glucocorticoids." in: Frontiers in neuroscience, Vol. 12, pp. 983, (2018) (PubMed).

Abdel-Hamid, El-Azab, Moustafa: "Macrolide antibiotics differentially influence human HepG2 cytotoxicity and modulate intrinsic/extrinsic apoptotic pathways in rat hepatocellular carcinoma model." in: Naunyn-Schmiedeberg's archives of pharmacology, Vol. 390, Issue 4, pp. 379-395, (2017) (PubMed).

Ochigbo, Saba, Oyagbemi, Omobowale, Asenuga: "Polyphenol-rich fraction of Parquetina nigrescens mitigates dichlorvos-induced neurotoxicity and apoptosis." in: Journal of Ayurveda and integrative medicine, Vol. 8, Issue 1, pp. 27-36, (2017) (PubMed).

Kubatka, Uramova, Kello, Kajo, Kruzliak, Mojzis, Vybohova, Adamkov, Jasek, Lasabova, Zubor, Fialova, Dokupilova, Solar, Pec, Adamicova, Danko, Adamek, Busselberg: "Antineoplastic effects of clove buds (Syzygium aromaticum L.) in the model of breast carcinoma." in: Journal of cellular and molecular medicine, (2017) (PubMed).

Wang, Xuan, Cui, Wang, Chen, Wei, Zhao: "Ibutilide treatment protects against ER stress induced apoptosis by regulating calumenin expression in tunicamycin treated cardiomyocytes." in: PLoS ONE, Vol. 12, Issue 4, pp. e0173469, (2017) (PubMed).

He, Chen, Yuan, Zhao, Chen, Wang, Li: "Tumor pH-Responsive Release of Drug-Conjugated Micelles from Fiber Fragments for Intratumoral Chemotherapy." in: ACS applied materials & interfaces, Vol. 9, Issue 38, pp. 32534-32544, (2017) (PubMed).

Li, Shi, Zhao, Li: "Long noncoding RNA CCAT1 functions as a ceRNA to antagonize the effect of miR-410 on the down-regulation of ITPKB in human HCT-116 and HCT-8 cells." in: Oncotarget, Vol. 8, Issue 54, pp. 92855-92863, (2017) (PubMed).

Wu, Ye, Zhou, Wang, Xie, Zhang, Gao, Zhang, Zhou, Zhuang, Liu, Hang, Shi: "Roles of Pannexin-1 Channels in Inflammatory Response through the TLRs/NF-Kappa B Signaling Pathway Following Experimental Subarachnoid Hemorrhage in Rats." in: Frontiers in molecular neuroscience, Vol. 10, pp. 175, (2017) (PubMed).

Xu, Sun, Ren, Yang, Tian, Peng: "Resveratrol controlled the fate of porcine pancreatic stem cells through the Wnt/β-catenin signaling pathway mediated by Sirt1." in: PLoS ONE, Vol. 12, Issue 10, pp. e0187159, (2017) (PubMed).

Huang, Fan, Qiu: "TM4SF1 Promotes Proliferation, Invasion, and Metastasis in Human Liver Cancer Cells." in: International journal of molecular sciences, Vol. 17, Issue 5, (2017) (PubMed).

Clark, Coury, Meilhac, Petty: "WO3/Pt nanoparticles are NADPH oxidase biomimetics that mimic effector cells in vitro and in vivo." in: Nanotechnology, Vol. 27, Issue 6, pp. 65101, (2016) (PubMed).

Kubatka, Kello, Kajo, Kruzliak, Výbohová, Mojžiš, Adamkov, Fialová, Veizerová, Zulli, Péč, Statelová, Grančai, Büsselberg: "Oregano demonstrates distinct tumour-suppressive effects in the breast carcinoma model." in: European journal of nutrition, (2016) (PubMed).

Yoshinaga, Kajiya, Oishi, Kamada, Ikeda, Chigwechokha, Kibe, Kishida, Kishida, Komatsu, Shiozaki: "NEU3 inhibitory effect of naringin suppresses cancer cell growth by attenuation of EGFR signaling through GM3 ganglioside accumulation." in: European journal of pharmacology, Vol. 782, pp. 21-9, (2016) (PubMed).
抗原

Caspase 3 (CASP3)

别名

Caspase 3 (CASP3 产品)

别名

CPP32 antibody, CPP32B antibody, SCA-1 antibody, A830040C14Rik antibody, AC-3 antibody, Apopain antibody, CC3 antibody, Caspase-3 antibody, Lice antibody, Yama antibody, mldy antibody, xcpp32 antibody, casp3 antibody, zgc:100890 antibody, CASP-3 antibody, caspase-3 antibody, caspase 3 antibody, caspase 3 S homeolog antibody, caspase 3, apoptosis-related cysteine peptidase a antibody, caspase 3, apoptosis-related cysteine peptidase antibody, CASP3 antibody, Casp3 antibody, casp3.S antibody, casp3a antibody

背景

Synonyms: CPP32, SCA-1, CPP32B, Caspase-3, CASP-3, Apopain, Cysteine protease CPP32, CPP-32, Protein Yama, SREBP cleavage activity 1, CASP3
Background: Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.

基因ID

836

UniProt

P42574

途径

Apoptosis, Caspase Cascade in Apoptosis, Sensory Perception of Sound, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Activated T Cell Proliferation