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SQSTM1 抗体 (AA 51-150)

Name: SQSTM1 抗体 (AA 51-150)
SKU: ABIN682153
Availability: OutOfStock

SQSTM1 适用: 人, 小鼠, 大鼠, Cow WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

HeLa cell lysates probed with Anti-SQSTM1 Polyclonal Antibody, Unconjugated at 1:5000 for 90 min at 37˚C.

ELISA

Formalin-fixed and paraffin embedded rat brain labeled with Anti-SQSTM1 Polyclonal Antibody, Unconjugated (ABIN682153) at 1:200, followed by conjugation to the secondary antibody and DAB staining

IHC

L1 rat kidney lysates, L2 rat brain lysates probed : Anti-GDF9 (ABIN682153) at 1:200 in 4 °C.

SDS

L1 rat kidney lysates, L2 rat brain lysates probed : Anti-GDF9 at 1:200 in 4˚C.

CQ inhibited matrine-induced autophagic flux in HepG2 and Bel7402 cells.

Effects of beclin-1 knockdown on matrine-induced autophagic flux and apoptosis in HepG2 and Bel7402 cells.

7 images

(5 references)

产品编号 ABIN682153

发货至: 中国

Datasheet as PDF

抗原 See all SQSTM1 抗体

SQSTM1 (Sequestosome 1 (SQSTM1))
抗原表位
19

17

14

13

8

7

7

7

7

6

6

5

3

3

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 51-150
适用
154

63

60

17

4

4

4

4

3

2

2

2

1

1

1

1
人, 小鼠, 大鼠, Cow
宿主
128

24

1

1
兔
Compatible Secondaries
克隆类型
127

27
多克隆
标记
75

11

10

7

7

6

5

5

5

5

5

5

1

1

1

1

1

1

1

1
This SQSTM1 antibody is un-conjugated
应用范围
104

57

41

40

22

18

16

16

13

12

10

4

3

2

2

1

1
Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

交叉反应

Cow, 人, 小鼠, 大鼠

预测反应

Dog,Cow,Sheep,Pig,Horse,Rabbit

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic peptide derived from human SQSTM1/Ubiquitin-binding protein p62

亚型

IgG

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SQSTM1 适用: 人, 猴 WB, IHC, IF, IHC (p), FACS 宿主: 小鼠 Monoclonal 5A2 unconjugated

anti-Sequestosome 1 (SQSTM1) antibody
KO Validated SQSTM1 适用: 人 WB, IHC, IF, IP 宿主: 兔 Monoclonal unconjugated

应用备注

WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
Kuo, Weng, Chang, Huang, Lin, Chuang, Lin, Liou, Tai, Lin, Wang: "Altered mitochondrial dynamics and response to insulin in cybrid cells harboring a diabetes-susceptible mitochondrial DNA haplogroup." in: Free radical biology & medicine, Vol. 96, pp. 116-29, (2016) (PubMed).

Xia, Gao, Zhang, Wang, Zhao, Che, Ao, Yang, Wang, Lei: "Autophagy mediated by arginine depletion activation of the nutrient sensor GCN2 contributes to interferon-γ-induced malignant transformation of primary bovine mammary epithelial cells." in: Cell death discovery, Vol. 2, pp. 15065, (2016) (PubMed).

Cui, Luo, Li, Li, Wang: "Changes of intracellular Ca2+ in quercetin-induced autophagy progression." in: Acta biochimica et biophysica Sinica, Vol. 47, Issue 11, pp. 908-14, (2015) (PubMed).

Chen, Wei, Nie, Lin, Tian, Liu, Yu, Cheng, Yan, Wang, Liu, Deng, Lai, Zhou, Zhang, Lin, Chen: "?-Asarone prevents autophagy and synaptic loss by reducing ROCK expression in asenescence-accelerated prone 8 mice." in: Brain research, Vol. 1552, pp. 41-54, (2014) (PubMed).

Wang, Gao, Yao, Xie: "Blocking autophagic flux enhances matrine-induced apoptosis in human hepatoma cells." in: International journal of molecular sciences, Vol. 14, Issue 12, pp. 23212-30, (2014) (PubMed).
抗原

SQSTM1 (Sequestosome 1 (SQSTM1))

别名

SQSTM1 (SQSTM1 产品)

别名

SQSTM1 antibody, sqstm1 antibody, MGC79491 antibody, A170 antibody, OSIL antibody, PDB3 antibody, ZIP3 antibody, p60 antibody, p62 antibody, p62B antibody, OSF-6 antibody, Osi antibody, STAP antibody, ZIP antibody, sb:cb621 antibody, zgc:85784 antibody, sequestosome 1 antibody, sequestosome 1 L homeolog antibody, SQSTM1 antibody, sqstm1 antibody, Sqstm1 antibody, sqstm1.L antibody

背景

Synonyms: p60, p62, A170, OSIL, PDB3, ZIP3, p62B, Sequestosome-1, EBI3-associated protein of 60 kDa, EBIAP, Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa, Ubiquitin-binding protein p62, SQSTM1, ORCA
Background: Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels.

基因ID

8878

UniProt

Q13501

途径

NF-kappaB Signaling, Neurotrophin Signaling Pathway, Autophagy