SREBF2 抗体 (AA 399-427)
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- 抗原 See all SREBF2 抗体
- SREBF2 (Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2))
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抗原表位
- AA 399-427
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SREBF2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- 免疫原
- This SREBF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 399-427 amino acids from the Central region of human SREBF2.
- 克隆位点
- RB24513
- 亚型
- Ig Fraction
- Top Product
- Discover our top product SREBF2 Primary Antibody
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anti-Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2) (AA 399-427) antibody
SREBF2 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2) (AA 75-164) antibodySREBF2 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2) (AA 1-220) antibodySREBF2 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2) antibodySREBF2 适用: 人, 大鼠, 小鼠, Pig WB, IHC (p), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2) (AA 801-900) antibodySREBF2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2) (AA 304-353) antibodySREBF2 适用: 人, 大鼠, 小鼠, Pig, 犬, Cow, 豚鼠, 马, 小鸡, Bat, Hamster, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2) (AA 434-483) antibodySREBF2 适用: 人, 大鼠, 小鼠, Pig, 犬, Cow, 豚鼠, 马, 小鸡, Bat, Hamster, 猴, 兔 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2) (AA 455-469) antibodySREBF2 适用: 人 WB, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2) (AA 402-431), (Middle Region) antibodySREBF2 适用: 人 WB, IF, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2) (AA 441-473) antibodySREBF2 适用: 斑马鱼 WB 宿主: 兔 Polyclonal RB49773 unconjugated
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- 应用备注
- IF: 1:10~50. WB: 1:1000. IHC-P: 1:10~50
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
- 有效期
- 6 months
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- 抗原
- SREBF2 (Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2))
- 别名
- SREBF2 (SREBF2 产品)
- 别名
- SREBF2 antibody, srebp2 antibody, SREBP2 antibody, zgc:158371 antibody, AI608257 antibody, SREBP-2 antibody, SREBP2gc antibody, bHLHd2 antibody, lop13 antibody, nuc antibody, Srebf2_retired antibody, sterol regulatory element binding transcription factor 2 antibody, sterol regulatory element binding factor 2 antibody, sterol regulatory element binding transcription factor 2 L homeolog antibody, SREBF2 antibody, srebf2 antibody, Srebf2 antibody, srebf2.L antibody
- 背景
- SREBPs, including SREBP-1a, SREBP-1c, and SREBP-2, constitute a family of basic helix-loop-helix (bHLH) transcription factors that play a critical role in lipid homeostasis by regulating genes involved in cholesterol and fatty acid metabolism. Each SREBP consists of three domains, including an amino-terminal transcription factor domain of ~480 amino acids, a middle hydrophobic region of ~80 amino acids containing two hydrophobic transmembrane segments, and a carboxy-terminal regulatory domain of ~590 amino acids. SREBP-2 regulates cholesterol synthesis by activating the transcription of genes for HMG-CoA reductase and other enzymes of the cholesterol synthetic pathway. SREBP-2 is ubiquitously detected in various tissues. Under basal conditions SREBP is bound to ER membranes as a glycosylated precursor protein. Upon cholesterol depletion, the protein is cleaved to its active forms (about 50-68 kDa) and translocated into the nucleus to stimulate transcription of genes involved in the uptake and synthesis of cholesterol.
- 分子量
- 123688
- 基因ID
- 6721
- NCBI登录号
- NP_004590
- UniProt
- Q12772
- 途径
- Regulation of Lipid Metabolism by PPARalpha
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