CYP27B1 抗体 (C-Term)
(4 references)Our Local Distributor
北京 101111
Quick Overview for CYP27B1 抗体 (C-Term) (ABIN652999)
抗原
See all CYP27B1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
抗原表位
- AA 482-508, C-Term
-
纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
-
免疫原
- This CYP27B1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 482-508 amino acids from the C-terminal region of human CYP27B1.
-
亚型
- Ig Fraction
-
-
anti-Cytochrome P450, Family 27, Subfamily B, Polypeptide 1 (CYP27B1) (AA 256-508) antibody
CYP27B1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome P450, Family 27, Subfamily B, Polypeptide 1 (CYP27B1) (AA 251-500) antibodyCYP27B1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome P450, Family 27, Subfamily B, Polypeptide 1 (CYP27B1) (AA 475-508), (C-Term) antibodyCYP27B1 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome P450, Family 27, Subfamily B, Polypeptide 1 (CYP27B1) (AA 258-504) antibodyCYP27B1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome P450, Family 27, Subfamily B, Polypeptide 1 (CYP27B1) (AA 477-508), (C-Term) antibodyCYP27B1 适用: 人 WB 宿主: 小鼠 Monoclonal 1981CT820-303-81 unconjugated
anti-Cytochrome P450, Family 27, Subfamily B, Polypeptide 1 (CYP27B1) (AA 400-429), (C-Term) antibodyCYP27B1 适用: 小鼠 WB 宿主: 兔 Polyclonal RB31024 unconjugated
anti-Cytochrome P450, Family 27, Subfamily B, Polypeptide 1 (CYP27B1) (AA 1-75) antibodyCYP27B1 适用: 斑马鱼 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome P450, Family 27, Subfamily B, Polypeptide 1 (CYP27B1) (AA 350-491) antibodyCYP27B1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- WB: 1:500. WB: 1:2000. IHC-P: 1:10~50. FC: 1:25
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- Avoid freeze-thaw cycles.
-
储存条件
- 4 °C,-20 °C
-
储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.
-
有效期
- 6 months
-
-
-
: "25(OH)D Is Effective to Repress Human Cholangiocarcinoma Cell Growth through the Conversion of 25(OH)D to 1α,25(OH)₂D₃." in: International journal of molecular sciences, Vol. 17, Issue 8, (2016) (PubMed).
: "Reduced sinonasal levels of 1?-hydroxylase are associated with worse quality of life in chronic rhinosinusitis with nasal polyps." in: International forum of allergy & rhinology, (2015) (PubMed).
: "Antenatal endotoxin disrupts lung vitamin D receptor and 25-hydroxyvitamin D 1?-hydroxylase expression in the developing rat." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 309, Issue 9, pp. L1018-26, (2015) (PubMed).
: "Cigarette smoke exposure is associated with vitamin D3 deficiencies in patients with chronic rhinosinusitis." in: The Journal of allergy and clinical immunology, Vol. 134, Issue 2, pp. 342-349.e1, (2014) (PubMed).
-
-
- CYP27B1 (Cytochrome P450, Family 27, Subfamily B, Polypeptide 1 (CYP27B1))
-
别名
- CYP27B1
-
背景
- CYP27B1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the inner mitochondrial membrane where it hydroxylates 25-hydroxyvitamin D3 at the 1alpha position. This reaction synthesizes 1alpha,25-dihydroxyvitamin D3, the active form of vitamin D3, which binds to the vitamin D receptor and regulates calcium metabolism. Thus this enzyme regulates the level of biologically active vitamin D and plays an important role in calcium homeostasis. Mutations in this gene can result in vitamin D-dependent rickets type I.
-
分子量
- 56504
-
基因ID
- 1594
-
NCBI登录号
- NP_000776
-
UniProt
- O15528
-
途径
- Metabolism of Steroid Hormones and Vitamin D
抗原
-
