电话:
400-7060-959
传真:
+86 10 56315212-8813
电子邮件:
orders@antibodies-online.cn

TPTEa 抗体 (N-Term)

适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB4973 unconjugated
产品编号 ABIN652246
发货至: 中国
  • 抗原 See all TPTEa products
    TPTEa
    抗原表位
    AA 42-74, N-Term
    适用
    宿主
    • 6
    克隆类型
    • 6
    多克隆
    标记
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TPTEa antibody is un-conjugated
    应用范围
    • 6
    • 6
    • 6
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    纯化方法
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    免疫原
    This TPTEa antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 42-74 amino acids from the N-terminal region of human TPTEa.
    克隆位点
    RB4973
    亚型
    Ig Fraction
  • 应用备注
    WB: 1:1000. IHC-P: 1:10~50
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    有效期
    6 months
  • 抗原
    TPTEa
    Abstract
    TPTEa 产品
    背景
    Ubiquitin is a 76 amino acid highly conserved eukaryotic polypeptide that selectively marks cellular proteins for proteolytic degradation by the 26S proteasome. The process of target selection, covalent attachment and shuttle to the 26S proteasome is a vital means of regulating the concentrations of key regulatory proteins in the cell by limiting their lifespans. Polyubiquitination is a common feature of this modification. Serial steps for modification include the activation of ubiquitin, an ATP-dependent formation of a thioester bond between ubiquitin and the enzyme E1, transfer by transacylation of ubiquitin from E1 to the ubiquitin conjugating enzyme E2, and covalent linkage to the target protein directly by E2 or via E3 ligase enzyme. Deubiquitination enzymes also exist to reverse the marking of protein substrates. Posttranslational tagging by Ub is involved in a multitude of cellular processes, including the cell cycle, cell growth and differentiation, embryogenesis, apoptosis, signal transduction, DNA repair, regulation of transcription and DNA replication, transmembrane transport, stress responses, the immune response, and nervous system functions.
    基因ID
    7179
    NCBI登录号
    NP_954868, NP_954869, NP_954870
    UniProt
    P56180
You are here:
客服