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SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 (SMARCA4) (C-Term) 抗体

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抗原
  • SMARCA4
  • BAF190
  • BAF190A
  • BRG1
  • MRD16
  • RTPS2
  • SNF2
  • SNF2L4
  • SNF2LB
  • SWI2
  • hSNF2b
  • brg-1
  • Brg1
  • HP1-BP72
  • SNF2beta
  • SW1/SNF
  • b2b692Clo
  • SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
  • SMARCA4
  • Smarca4
Alternatives
anti-人 SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 抗体 for Chromatin Immunoprecipitation
抗原表位
C-Term
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适用

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宿主
小鼠
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克隆类型 (克隆位点)
单克隆 ()
标记
非结合性
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应用范围
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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免疫原 Bacterially produced GST-fused protein representing 242 C-terminal amino acids of human Brg1
克隆位点 BRG-01
亚型 IgG2a
特异性 The antibody BRG-01 recognizes an epitope within C-terminal part of Human Brg1, a 205 kDa catalytic subunit of SWI2/SNF2-family chromatin-remodeling complexes.
交叉反应 (详细) Species reactivity (tested):Human
纯化方法 Protein-A affinity chromatography
纯度 > 95 % pure by SDS-PAGE
别名 SMARCA4 / BRG1 (SMARCA4 Antibody 摘要)
背景 Brg1 (Brahma-related gene 1) is an ATPase subunit of SWI2/SNF2-like chromatin-remodeling complexes that enable access of regulatory and effector proteins in transcription, DNA repair and DNA replication. Although Brg1-containing complexes are not essential for general cell survival, they participate in transcriptional regulation of several hundred genes including those involved in interferon and stress response, immune cells differentiation, neurogenesis, cell cycle etc. and is absolutely necessary for mouse embryogenesis. Brg1 is also involved in cell growth arrest, senescence and tumour supression.Synonyms: ATP-dependent helicase SMARCA4, BRG-1 protein, Brahma protein homolog 1, Mitotic growth and transcription activator, Probable global transcription activator SNF2L4, SNF2-beta, SNF2B, SNF2L4, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
基因ID 6597
NCBI登录号 NP_001122316
UniProt P51532
途径 Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Stem Cell Maintenance
应用备注 Optimal working dilution should be determined by the investigator.
限制 仅限研究用
浓度 1.0 mg/mL
缓冲液 PBS, pH ~7.4, 15 mM Sodium Azide
储存液 Sodium azide
注意事项 This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项 Avoid repeated freezing and thawing.
储存条件 4 °C/-20 °C
储存方法 Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for up to one month or (in aliquots) at -20 °C for longer.
厂商提供的图像
Western Blotting (WB) image for anti-SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 (SMARCA4) (C-Term) 抗体 (ABIN614772) anti-SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 (SMARCA4) (C-Term) antibody
背景 Griffin, Brennan, Magnuson: "The chromatin-remodeling enzyme BRG1 plays an essential role in primitive erythropoiesis and vascular development." in: Development (Cambridge, England), Vol. 135, Issue 3, pp. 493-500, 2008 (PubMed).

Napolitano, Cipollaro, Cascino, Melone, Giordano, Galderisi: "Brg1 chromatin remodeling factor is involved in cell growth arrest, apoptosis and senescence of rat mesenchymal stem cells." in: Journal of cell science, Vol. 120, Issue Pt 16, pp. 2904-11, 2007 (PubMed).

Ooi, Belyaev, Miyake, Wood, Buckley: "BRG1 chromatin remodeling activity is required for efficient chromatin binding by repressor element 1-silencing transcription factor (REST) and facilitates REST-mediated repression." in: The Journal of biological chemistry, Vol. 281, Issue 51, pp. 38974-80, 2006 (PubMed).

Eroglu, Wang, Tu, Sun, Mivechi: "Critical role of Brg1 member of the SWI/SNF chromatin remodeling complex during neurogenesis and neural crest induction in zebrafish." in: Developmental dynamics : an official publication of the American Association of Anatomists, Vol. 235, Issue 10, pp. 2722-35, 2006 (PubMed).

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