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CTLA4 抗体

CTLA4 适用: 人 FACS, ELISA, Func 宿主: 小鼠 Monoclonal ANC152-2-8H5 unconjugated
产品编号 ABIN610405
发货至: 中国
  • 抗原 See all CTLA4 抗体
    CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))
    适用
    • 91
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    宿主
    • 62
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    小鼠
    克隆类型
    • 77
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    单克隆
    标记
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    This CTLA4 antibody is un-conjugated
    应用范围
    • 80
    • 65
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    Flow Cytometry (FACS), ELISA, Functional Studies (Func)
    特异性
    CTLA-4 expressed on activated T cells.
    纯化方法
    Protein A purified
    免疫原
    Stimulated human PBL’,s and human CD152 Ig fusion protein.

    Type of Immunogen: Fusion protein
    克隆位点
    ANC152-2-8H5
    亚型
    IgG1 kappa
    Top Product
    Discover our top product CTLA4 Primary Antibody
  • 应用备注
    Approved: ELISA, Flo, Func

    Usage: Function: ANC152.2 blocks binding of CD152 (CTLA-4) Ig fusion protein to its CD80/CD86 receptor, and has been reported to modulate suppressive function of human T Regulatory Cells in Vitro. ANC152.2 can bind to intracellular CD152 in fixed permeabolized cells. The F(ab')2 form has been used to inhibit proliferation of activated T cells in vitro in a cholera toxin model. The applications listed have been tested for the unmodified form of this product. Other forms have not been tested.
    说明

    Target Species of Antibody: Human

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    Lot specific
    缓冲液
    50 mM sodium phosphate,  pH 7.5, 100 mM potassium chloride, 150 mM sodium chloride
    储存液
    Azide free
    注意事项
    Do not freeze. Open under aseptic conditions.
    储存条件
    4 °C
    储存方法
    Store at 4°C. Do not freeze. Open under aseptic conditions.
  • Zundel, Swiersz, Giaccia: "Caveolin 1-mediated regulation of receptor tyrosine kinase-associated phosphatidylinositol 3-kinase activity by ceramide." in: Molecular and cellular biology, Vol. 20, Issue 5, pp. 1507-14, (2000) (PubMed).

    Chitaev, Troyanovsky: "Adhesive but not lateral E-cadherin complexes require calcium and catenins for their formation." in: The Journal of cell biology, Vol. 142, Issue 3, pp. 837-46, (1998) (PubMed).

    Behrens, Vakaet, Friis, Winterhager, Van Roy, Mareel, Birchmeier et al.: "Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/beta-catenin complex in cells transformed with a temperature-sensitive v-SRC ..." in: The Journal of cell biology, Vol. 120, Issue 3, pp. 757-66, (1993) (PubMed).

  • 抗原
    CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))
    别名
    CTLA4 / CD152 (CTLA4 产品)
    别名
    CTLA-4 antibody, CTLA4 antibody, CD152 antibody, Cd152 antibody, Ctla-4 antibody, Ly-56 antibody, CD antibody, CELIAC3 antibody, GRD4 antibody, GSE antibody, IDDM12 antibody, sCTLA4 antibody, cytotoxic T-lymphocyte associated protein 4 antibody, cytotoxic T-lymphocyte-associated protein 4 antibody, CTLA4 antibody, Ctla4 antibody
    背景
    Name/Gene ID: CTLA4

    Synonyms: CTLA4, CD152, CELIAC3, CD152 antigen, CTLA-4, Celiac disease 3, IDDM12, GRD4, GSE, CD152 isoform
    基因ID
    1493
    UniProt
    P16410
    途径
    Cancer Immune Checkpoints
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