GRAP2 抗体
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- 抗原 See all GRAP2 抗体
- GRAP2 (GRB2-Related Adaptor Protein 2 (GRAP2))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This GRAP2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunoprecipitation (IP), Flow Cytometry (FACS)
- 特异性
- This antibody detects recognizes GRAP2/GADS, a 41 kDa cytoplasmic adaptor protein that plays a pivotal role during the early events of signal transduction in T cells.
- 交叉反应 （详细）
- Species reactivity (tested):Human
- 纯化方法
- Protein-A affinity chromatography
- 免疫原
- GST-fusion human GRAP2/GADS protein
- 克隆位点
- UW40
- 亚型
- IgG2a
- Top Product
- Discover our top product GRAP2 Primary Antibody
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anti-GRB2-Related Adaptor Protein 2 (GRAP2) (AA 226-315) antibody
GRAP2 适用: 人 WB, ELISA, IP, IHC (p) 宿主: 小鼠 Monoclonal 1G12 unconjugated
anti-GRB2-Related Adaptor Protein 2 (GRAP2) (AA 1-330) antibodyGRAP2 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-GRB2-Related Adaptor Protein 2 (GRAP2) (AA 1-330) antibodyGRAP2 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-GRB2-Related Adaptor Protein 2 (GRAP2) (C-Term) antibodyVerified GRAP2 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-GRB2-Related Adaptor Protein 2 (GRAP2) antibodyGRAP2 适用: 人 WB, IP, FACS 宿主: 小鼠 Monoclonal UW40 unconjugated
anti-GRB2-Related Adaptor Protein 2 (GRAP2) (AA 20-262) antibodyGRAP2 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-GRB2-Related Adaptor Protein 2 (GRAP2) antibody (APC)GRAP2 适用: 人 FACS 宿主: 小鼠 Monoclonal UW40 APC
anti-GRB2-Related Adaptor Protein 2 (GRAP2) antibody (PE)GRAP2 适用: 人 FACS 宿主: 小鼠 Monoclonal UW40 PE
anti-GRB2-Related Adaptor Protein 2 (GRAP2) antibodyGRAP2 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-GRB2-Related Adaptor Protein 2 (GRAP2) (AA 149-251) antibodyGRAP2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 浓度
- 1.0 mg/mL
- 缓冲液
- Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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- 抗原
- GRAP2 (GRB2-Related Adaptor Protein 2 (GRAP2))
- 别名
- GRAP2 (GRAP2 产品)
- 别名
- GADS antibody, GRAP-2 antibody, GRB2L antibody, GRBLG antibody, GRID antibody, GRPL antibody, GrbX antibody, Grf40 antibody, Mona antibody, P38 antibody, Gads antibody, GrpL antibody, zgc:112091 antibody, GRAP2 antibody, grap2 antibody, zgc:65942 antibody, GRB2-related adaptor protein 2 antibody, GRB2-related adaptor protein 2a antibody, GRB2-related adaptor protein 2b antibody, GRAP2 antibody, Grap2 antibody, grap2a antibody, grap2 antibody, grap2b antibody
- 背景
- GRAP2/GADS (Grb2-related adaptor protein 2 / Grb2-related adaptor downstream of Shc) is a cytoplasmic adaptor protein containing N- and C-terminal SH3 domains flanking a central SH2 domain and a proline/glutamine-rich region. It is expressed predominantly in lymphoid tissue and hematopoietic cells, particularly in T cells. GRAP2/GADS plays a pivotal role during the early events of T cell signal transduction by recruiting the adaptor protein SLP-76 and its associated molecules, such as Vav, Nck, Itk, and ADAP, to the transmembrane adaptor protein LAT. GRAP2/GADS also binds several other signaling proteins, namely Gab2, HPK1 (hematopoietic progenitor kinase 1), and Cbl. Unlike similar adaptor protein Grb2, GRAP2/GADS shows higher selectivity when binding to the particular phosphorylated tyrosines of LAT adaptor.Synonyms: Adapter protein GRID, GADS, GRB-2-like protein, GRB2-related adapter protein 2, GRB2L, GRBLG, GRBX, GRID, Grf-40, Grf40 adapter protein, Growth factor receptor-binding protein, Hematopoietic cell-associated adapter protein GrpL, SH3-SH2-SH3 adapter Mona
- 基因ID
- 9402
- NCBI登录号
- NP_004801
- UniProt
- O75791
- 途径
- TCR Signaling, Fc-epsilon Receptor Signaling Pathway
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