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Caspase 12 抗体 (N-Term)

CASP12 适用: 人, 小鼠, 大鼠 WB, IF, IP 宿主: 大鼠 Monoclonal 14F4 unconjugated
产品编号 ABIN567796
发货至: 中国
  • 抗原 See all Caspase 12 (CASP12) 抗体
    Caspase 12 (CASP12) (Caspase 12 (Gene/pseudogene) (CASP12))
    抗原表位
    • 16
    • 15
    • 8
    • 7
    • 6
    • 6
    • 6
    • 6
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 95-318, N-Term
    适用
    人, 小鼠, 大鼠
    宿主
    • 89
    • 3
    • 1
    大鼠
    克隆类型
    • 90
    • 3
    单克隆
    标记
    • 40
    • 8
    • 6
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This Caspase 12 antibody is un-conjugated
    应用范围
    • 79
    • 40
    • 29
    • 28
    • 26
    • 26
    • 21
    • 19
    • 10
    • 6
    • 5
    • 5
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)
    特异性
    This antibody reacts with Caspase-12 (~53 kDa) on Western blotting, Immunoprecipitation and Immunocytochemistry.
    纯化方法
    Protein-G Agarose Chromatography of hybridoma supernatant.
    免疫原
    Recombinant Caspase-12 N-terminal fragment (aa 95-318).
    克隆位点
    14F4
    亚型
    IgG2a
    Top Product
    Discover our top product CASP12 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 浓度
    1.0 mg/mL
    缓冲液
    PBS, pH 7.2 containing 50 % Glycerol without preservatives.
    储存液
    Without preservative
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    -20 °C
    储存方法
    Store the antibody (in aliquots) at -20 °C.
  • 抗原
    Caspase 12 (CASP12) (Caspase 12 (Gene/pseudogene) (CASP12))
    别名
    Caspase-12 (CASP12 产品)
    别名
    Caspase-12 antibody, CASP-12 antibody, CASP12P1 antibody, caspase 12 antibody, caspase 12 (gene/pseudogene) antibody, Casp12 antibody, CASP12 antibody
    背景
    Caspase-12 is localized to the endoplasmic reticulum (ER), but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis and accumulation of excess proteins in ER, but not by membrane- or mitochondrial-targeted apoptotic signals. One well-known cause of ER stress in neurons is the accretion of amyloid-beta, the insoluble protein that forms plaques in the brains of patients with Alzheimer's disease. Caspase-12 mediates cytotoxicity induced by amyloid-beta and ER stress-induced apoptosis. Caspase-12 is ubiquitously expressed in tissues. Similar to other members of the Caspase family, Caspase-12 requires cleavage of the prodomain to activate its proapoptotic form.Synonyms: CASP-12, CASP12, Inactive caspase-12
    基因ID
    100506742
    NCBI登录号
    NP_001177945
    UniProt
    Q6UXS9
    途径
    Apoptosis, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response
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