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MAD2L1 抗体 (MAD2 Mitotic Arrest Deficient-Like 1 (Yeast))

Details for Product anti-MAD2L1 Antibody No. ABIN567786, 供应商: Log in to see
抗原
  • cb408
  • zgc:112133
  • MAD2L1
  • mad2
  • XMad2
  • AA673185
  • MAD2
  • HSMAD2
  • MAD2 mitotic arrest deficient-like 1 (yeast)
  • MAD2 mitotic arrest deficient-like 1
  • MAD2L1
  • mad2l1
  • LOC100218172
  • Mad2l1
适用
人, 小鼠, 大鼠
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32
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4
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2
2
1
宿主
小鼠
72
33
15
1
克隆类型 (克隆位点)
单克隆 ()
标记
This MAD2L1 antibody is un-conjugated
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
应用范围
Immunoprecipitation (IP), Western Blotting (WB)
102
46
22
22
21
20
13
6
2
1
1
1
1
1
Supplier
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免疫原 Recombinant Human MAD2.
克隆位点 2G9
亚型 IgG1
特异性 This antibody reacts with MAD2 (25 kDa) on Western blotting and Immunoprecipitation.
纯化方法 Protein-A Agarose Chromatography of hybridoma supernatant.
别名 MAD2L1 (MAD2L1 Antibody 摘要)
背景 Some of the spindle checkpoint components are evolutionarily conserved from yeast to human. They include mitotic arrest deficiency 1 (MAD1), MAD2, MAD3/BUBR1, budding uninhibited by benomyl 1 (BUB1), BUB3, and monopolar spindle 1 (MPS1). MAD1 interacts with several checkpoint proteins, forming a complex with MAD2 and recruiting MAD2 to unattached kinetochores. MAD1 and Cdc20 can bind MAD2, but these two bindings are exclusive. They share a 10-residue MAD2-binding motif. It has been suggested that MAD1 acts as a positive regulator and a competitive inhibitor of the MAD2-Cdc20 complex.Synonyms: MAD2, Mitotic spindle assembly checkpoint protein MAD2A
基因ID 4085
NCBI登录号 NP_002349
UniProt Q13257
研究领域 Cell Cycle
应用备注 Optimal working dilution should be determined by the investigator.
限制 仅限研究用
浓度 1.0 mg/mL
缓冲液 PBS, pH 7.2 containing 50 % Glycerol without preservatives.
储存液 Without preservative
注意事项 Avoid repeated freezing and thawing.
储存条件 -20 °C
储存方法 Store the antibody (in aliquots) at -20 °C.
厂商提供的图像
Western Blotting (WB) image for anti-MAD2L1 抗体 (MAD2 Mitotic Arrest Deficient-Like 1 (Yeast)) (ABIN567786) anti-MAD2 Mitotic Arrest Deficient-Like 1 (Yeast) (MAD2L1) antibody
Western Blotting (WB) image for anti-MAD2L1 抗体 (MAD2 Mitotic Arrest Deficient-Like 1 (Yeast)) (ABIN567786) anti-MAD2 Mitotic Arrest Deficient-Like 1 (Yeast) (MAD2L1) antibody (Image 2)
背景 Wei, Chou, Ou, Yeh, Tyan, Sun, Shen, Shieh: "TTK/hMps1 participates in the regulation of DNA damage checkpoint response by phosphorylating CHK2 on threonine 68." in: The Journal of biological chemistry, Vol. 280, Issue 9, pp. 7748-57, 2005 (PubMed).

Sudakin, Chan, Yen: "Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2." in: The Journal of cell biology, Vol. 154, Issue 5, pp. 925-36, 2001 (PubMed).