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TARDBP 抗体 (AA 1-260)

TARDBP 适用: 人 WB, ELISA, IF, IP, IHC (p), RNAi 宿主: 小鼠 Monoclonal 2E2-D3 unconjugated
产品编号 ABIN565080
发货至: 中国
  • 抗原 See all TARDBP 抗体
    TARDBP (TAR DNA Binding Protein (TARDBP))
    抗原表位
    • 15
    • 12
    • 11
    • 9
    • 7
    • 7
    • 7
    • 7
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-260
    适用
    • 100
    • 59
    • 59
    • 13
    • 8
    • 8
    • 7
    • 6
    • 6
    • 5
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    宿主
    • 103
    • 13
    • 1
    小鼠
    克隆类型
    • 94
    • 23
    单克隆
    标记
    • 64
    • 7
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This TARDBP antibody is un-conjugated
    应用范围
    • 85
    • 47
    • 33
    • 31
    • 20
    • 17
    • 14
    • 13
    • 13
    • 7
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), RNA Interference (RNAi)
    原理
    Mouse monoclonal antibody raised against a partial recombinant TARDBP.
    序列
    MSEYIRVTED ENDEPIEIPS EDDGTVLLST VTAQFPGACG LRYRNPVSQC MRGVRLVEGI LHAPDAGWGN LVYVVNYPKD NKRKMDETDA SSAVKVKRAV QKTSDLIVLG LPWKTTEQDL KEYFSTFGEV LMVQVKKDLK TGHSKGFGFV RFTEYETQVK VMSQRHMIDG RWCDCKLPNS KQSQDEPLRS RKVFVGRCTE DMTEDELREF FSQYGDVMDV FIPKPFRAFA FVTFADDQIA QSLCGEDLII KGISVHISNA
    交叉反应
    产品特性
    Antibody Reactive Against Recombinant Protein.
    免疫原
    TARDBP (NP_031401.1, 1 a.a. ~ 260 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
    克隆位点
    2E2-D3
    亚型
    IgG1
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 缓冲液
    In 1x PBS, pH 7.4
    注意事项
    Aliquot to avoid repeated freezing and thawing.
    储存条件
    -20 °C
    储存方法
    Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
  • Lynch, Jaunmuktane, Sheerin, Phadke, Brandner, Milonas, Dean, Bajaj, McNicholas, Costello, Cronin, McGuigan, Rossor, Fox, Murphy, Chataway, Houlden: "Hereditary leukoencephalopathy with axonal spheroids: a spectrum of phenotypes from CNS vasculitis to parkinsonism in an adult onset leukodystrophy series." in: Journal of neurology, neurosurgery, and psychiatry, Vol. 87, Issue 5, pp. 512-9, (2016) (PubMed).

    De Marco, Lomartire, Calvo, Risso, De Luca, Mostert, Mandrioli, Caponnetto, Borghero, Manera, Canosa, Moglia, Restagno, Fini, Tarella, Giordana, Rinaudo, Chiò: "Monocytes of patients with amyotrophic lateral sclerosis linked to gene mutations display altered TDP-43 subcellular distribution." in: Neuropathology and applied neurobiology, Vol. 43, Issue 2, pp. 133-153, (2016) (PubMed).

    Gelpi, Höftberger, Graus, Ling, Holton, Dawson, Popovic, Pretnar-Oblak, Högl, Schmutzhard, Poewe, Ricken, Santamaria, Dalmau, Budka, Revesz, Kovacs: "Neuropathological criteria of anti-IgLON5-related tauopathy." in: Acta neuropathologica, Vol. 132, Issue 4, pp. 531-43, (2016) (PubMed).

    Rosenbohm, Buckert, Gerischer, Walcher, Kassubek, Rottbauer, Ludolph, Bernhardt: "Early diagnosis of cardiac involvement in idiopathic inflammatory myopathy by cardiac magnetic resonance tomography." in: Journal of neurology, Vol. 262, Issue 4, pp. 949-56, (2015) (PubMed).

    Iovino, Pfisterer, Holton, Lashley, Swingler, Calo, Treacy, Revesz, Parmar, Goedert, Muqit, Spillantini: "The novel MAPT mutation K298E: mechanisms of mutant tau toxicity, brain pathology and tau expression in induced fibroblast-derived neurons." in: Acta neuropathologica, Vol. 127, Issue 2, pp. 283-95, (2014) (PubMed).

    Hebron, Chen, Miessau, Lonskaya, Moussa: "Parkin reverses TDP-43-induced cell death and failure of amino acid homeostasis." in: Journal of neurochemistry, Vol. 129, Issue 2, pp. 350-61, (2014) (PubMed).

    Suárez-Calvet, Dols-Icardo, Lladó, Sánchez-Valle, Hernández, Amer, Antón-Aguirre, Alcolea, Fortea, Ferrer, van der Zee, Dillen, Van Broeckhoven, Molinuevo, Blesa, Clarimón, Lleó: "Plasma phosphorylated TDP-43 levels are elevated in patients with frontotemporal dementia carrying a C9orf72 repeat expansion or a GRN mutation." in: Journal of neurology, neurosurgery, and psychiatry, Vol. 85, Issue 6, pp. 684-91, (2014) (PubMed).

    Yan, Wang, Wei, Gaertig, Lai, Li, Li: "TDP-43 causes differential pathology in neuronal versus glial cells in the mouse brain." in: Human molecular genetics, Vol. 23, Issue 10, pp. 2678-93, (2014) (PubMed).

    De Marco, Lomartire, Mandili, Lupino, Buccinnà, Ramondetti, Moglia, Novelli, Piccinini, Mostert, Rinaudo, Chiò, Calvo: "Reduced cellular Ca(2+) availability enhances TDP-43 cleavage by apoptotic caspases." in: Biochimica et biophysica acta, Vol. 1843, Issue 4, pp. 725-34, (2014) (PubMed).

    Cortese, Plagnol, Brady, Simone, Lashley, Acevedo-Arozena, de Silva, Greensmith, Holton, Hanna, Fisher, Fratta: "Widespread RNA metabolism impairment in sporadic inclusion body myositis TDP43-proteinopathy." in: Neurobiology of aging, Vol. 35, Issue 6, pp. 1491-8, (2014) (PubMed).

    Ohta, Tremblay, Schneider, Bennett, Calon, Julien: "Interaction of transactive response DNA binding protein 43 with nuclear factor ?B in mild cognitive impairment with episodic memory deficits." in: Acta neuropathologica communications, Vol. 2, Issue 1, pp. 37, (2014) (PubMed).

    Gelpi, Navarro-Otano, Tolosa, Gaig, Compta, Rey, Martí, Hernández, Valldeoriola, Reñé, Ribalta: "Multiple organ involvement by alpha-synuclein pathology in Lewy body disorders." in: Movement disorders : official journal of the Movement Disorder Society, Vol. 29, Issue 8, pp. 1010-8, (2014) (PubMed).

    Carlomagno, Zhang, Davis, Lin, Cook, Dunmore, Tay, Menkosky, Cao, Petrucelli, Deture: "Casein kinase II induced polymerization of soluble TDP-43 into filaments is inhibited by heat shock proteins." in: PLoS ONE, Vol. 9, Issue 3, pp. e90452, (2014) (PubMed).

    Kara, Kiely, Proukakis, Giffin, Love, Hehir, Rantell, Pandraud, Hernandez, Nacheva, Pittman, Nalls, Singleton, Revesz, Bhatia, Quinn, Hardy, Holton, Houlden: "A 6.4 Mb duplication of the ?-synuclein locus causing frontotemporal dementia and Parkinsonism: phenotype-genotype correlations." in: JAMA neurology, Vol. 71, Issue 9, pp. 1162-71, (2014) (PubMed).

    Balasa, Gelpi, Rey, Vila, Ramió-Torrentà, Quiles Granado, Molina Latorre, Lepidi, Raoult, Saiz: "Clinical and neuropathological variability in clinically isolated central nervous system Whipple's disease." in: Brain pathology (Zurich, Switzerland), Vol. 24, Issue 3, pp. 230-8, (2014) (PubMed).

    Araki, Minegishi, Motoki, Kume, Hohjoh, Araki, Tamaoka: "Disease-associated mutations of TDP-43 promote turnover of the protein through the proteasomal pathway." in: Molecular neurobiology, Vol. 50, Issue 3, pp. 1049-58, (2014) (PubMed).

    Hans, Fiesel, Strong, Jäckel, Rasse, Geisler, Springer, Schulz, Voigt, Kahle: "UBE2E ubiquitin-conjugating enzymes and ubiquitin isopeptidase Y regulate TDP-43 protein ubiquitination." in: The Journal of biological chemistry, Vol. 289, Issue 27, pp. 19164-79, (2014) (PubMed).

    Robinson, Thompson, Weedon, Rollinson, Pickering-Brown, Snowden, Davidson, Mann: "No interaction between tau and TDP-43 pathologies in either frontotemporal lobar degeneration or motor neurone disease." in: Neuropathology and applied neurobiology, Vol. 40, Issue 7, pp. 844-54, (2014) (PubMed).

    Alafuzoff, Pikkarainen, Neumann, Arzberger, Al-Sarraj, Bodi, Bogdanovic, Bugiani, Ferrer, Gelpi, Gentleman, Giaccone, Graeber, Hortobagyi, Ince, Ironside, Kavantzas, King, Korkolopoulou, Kovács et al.: "Neuropathological assessments of the pathology in frontotemporal lobar degeneration with TDP43-positive inclusions: an inter-laboratory study by the BrainNet Europe consortium. ..." in: Journal of neural transmission (Vienna, Austria : 1996), (2014) (PubMed).

    Wenqiang, Lonskaya, Hebron, Ibrahim, Olszewski, Neale, Moussa: "Parkin-mediated reduction of nuclear and soluble TDP-43 reverses behavioral decline in symptomatic mice." in: Human molecular genetics, Vol. 23, Issue 18, pp. 4960-9, (2014) (PubMed).

  • 抗原
    TARDBP (TAR DNA Binding Protein (TARDBP))
    别名
    TARDBP (TARDBP 产品)
    别名
    TARDBP antibody, TDP43 antibody, DKFZp459I2127 antibody, tardbp antibody, ALS10 antibody, TDP-43 antibody, 1190002A23Rik antibody, C85084 antibody, Tdp43 antibody, wu:fb77f02 antibody, wu:fc52g10 antibody, TAR DNA binding protein antibody, Tardbp protein antibody, TAR DNA binding protein L homeolog antibody, TAR DNA-binding protein 43-like antibody, TARDBP antibody, tardbp antibody, tardbp.L antibody, Tardbp antibody, LOC100621383 antibody
    背景
    Full Gene Name: TAR DNA binding protein
    Synonyms: ALS10,TDP-43
    基因ID
    23435
    NCBI登录号
    NM_007375
    途径
    Positive Regulation of Peptide Hormone Secretion
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