ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) (AA 262-277) 抗体

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抗原
  • MDR1
  • xemdr
  • ABC20
  • CD243
  • CLCS
  • GP170
  • P-GP
  • PGY1
  • p-gp
  • Abcb1
  • Mdr1a
  • ABCB1
  • PGP1
  • Mdr1
  • Mdr1b
  • Pgy-1
  • Pgy1
  • mdr
  • Mdr
  • Cd243
  • Mdr-1
  • Mod-2
  • Mod-2r
  • Mod-2s
  • Mod2-r
  • Mod2-s
  • ATP-binding cassette, sub-family B (MDR/TAP), member 1
  • ATP-binding cassette, sub-family B (MDR/TAP), member 1A
  • ATP-binding cassette, sub-family B (MDR/TAP), member 1B
  • ATP-binding cassette, subfamily B (MDR/TAP), member 1B
  • malic enzyme complex, mitochondrial
  • ABCB1
  • abcb1
  • Abcb1a
  • Abcb1b
  • Mod2
抗原表位
AA 262-277
38
36
13
9
7
4
3
3
3
2
2
2
2
2
1
1
1
1
1
适用
犬, 人, 猴, 小鼠, 大鼠
268
27
17
13
10
7
7
2
2
1
1
1
1
1
1
1
1
1
宿主

182
97
克隆类型
多克隆
标记
非结合性
14
9
9
7
5
5
4
4
4
4
4
4
4
4
4
3
2
2
2
2
2
1
1
1
应用范围
Enzyme Immunoassay (EIA), Western Blotting (WB)
140
82
75
74
37
35
24
23
8
7
6
3
3
2
2
2
1
选项
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免疫原 Synthetic peptide corresponding to amino acids 262-277 of Human ABCB1 protein.
亚型 IgG
特异性 This antibody is directed against Human ABCB1 protein.
交叉反应 (详细) Species reactivity (expected):Monkey, Canine, Mouse and Rat.
Species reactivity (tested):Human.
产品特性 Concentration: 1.28 mg/mL (by UV absorbance at 280 nm)
纯化方法 Immunoaffinity Chromatography.
别名 CD243 / MDR1 (ABCB1 Antibody 摘要)
背景 ATP-Binding Cassette Sub-Family B Member 1 (ABCB1, also named P-glycoprotein) is a plasma membrane-associated multidrug transporter that utilizes the energy of ATP hydrolysis to pump toxic xenobiotics out of cells. Unique features of ABCB1 are its very broad substrate specificity and its basal ATPase activity in the absence of transport substrates. Human ABCB1 plays an important role in absorption, distribution, metabolism, excretion and toxicity of pharmacologically relevant drugs. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anti-cancer drugs. This protein also functions as a transporter across the blood-brain barrier.Synonyms: ABCB1, ATP-binding cassette sub-family B member 1, Multidrug resistance protein 1, P-glycoprotein 1, PGY1
基因ID 5243
NCBI登录号 NP_000918
UniProt P08183
应用备注 ELISA: 1/10,000-1/50,000. Western Blot: 1/200-1/2,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
限制 仅限研究用
浓度 1.28 mg/mL
缓冲液 0.02 M Potassium Phosphate, 0.12 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide as preservative.
储存液 Sodium azide
注意事项 This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项 Avoid repeated freezing and thawing.
储存条件 4 °C/-20 °C
储存方法 Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer. Dilute only prior to to immediate use.
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