NEW: 请通过本地经销商订购 4A Biotech Co.,Ltd.

Tumor Necrosis Factor 抗体 (TNF)

Details for Product anti-TNF Antibody No. ABIN5526232, 供应商: Log in to see
抗原
  • TNF
  • tnf
  • dif
  • tnfa
  • xtnf
  • TNF-a
  • tnfsf2
  • tnf-alpha
  • TNF-alpha
  • DIF
  • TNFA
  • TNFSF2
  • TNFalpha
  • Tnfa
  • Tnfsf1a
  • RATTNF
  • TNFa
  • cTNF
  • TNF-ALPHA
  • Cachectin
  • Tnf-alpha
  • tnfa-like
  • tumor necrosis factor (TNF superfamily, member 2)
  • tumor necrosis factor
  • tumour necrosis factor alpha-like
  • tumor necrosis factor alpha
  • lipopolysaccharide-induced TNF factor
  • tumor necrosis factor b (TNF superfamily, member 2)
  • TNF
  • tnf
  • tnf-alpha
  • LITAF
  • Tnf
  • tnfb
Alternatives
anti-人 Tumor Necrosis Factor 抗体 for Activity Inhibition
适用

1254
460
358
145
136
119
119
63
55
41
29
18
14
12
9
7
6
4
4
4
4
2
1
1
1
1
宿主
Mammalian Cells
940
516
184
48
10
9
7
6
4
3
1
抗体类型
Recombinant Antibody
克隆类型 (克隆位点)
单克隆 ()
标记
This Tumor Necrosis Factor antibody is un-conjugated
169
100
74
50
32
30
28
27
26
25
25
25
25
25
24
24
24
23
13
9
4
4
4
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
应用范围
ELISA, Flow Cytometry (FACS), In vivo Studies (in vivo)
886
859
621
322
286
230
219
190
137
118
98
74
29
27
26
22
20
18
14
9
7
7
6
6
6
5
5
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Get this product for free

It's quick and easy to submit your validation proposal. I want to validate this product

Learn more

原理 Monoclonal antibody to detect TNF alpha in human samples.
免疫原 Purified recombinant human TNF (rTNF)
克隆位点 CA2
亚型 IgG1 kappa
纯化方法 Affinity purified using protein A
别名 TNF (TNF Antibody 摘要)
背景 Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line.
Synonyms: TNF-α, TNFα, TNFSF, Tumor necrosis factor, Cachectin, TNF-alpha, Tumor necrosis factor ligand superfamily member 2, TNF-a, TNFa
基因ID 7124
UniProt P01375
途径 NF-kappaB Signaling, Apoptosis, Caspase Cascade in Apoptosis, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus
应用备注 Optimal working dilution should be determined by the investigator.
限制 仅限研究用
状态 Liquid
缓冲液 200 μg affinity purified human antibody in phosphate-buffered saline (PBS) containing 0.02 % Proclin 300
储存液 ProClin
注意事项 This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项 The antibody solution should be gently mixed before use
储存条件 -20 °C
有效期 12 months