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Cyclin D1 抗体 (N-Term)

Name: Cyclin D1 抗体 (N-Term)
SKU: ABIN5518654
Availability: OutOfStock

CCND1 适用: 人, 大鼠 WB 宿主: 兔 Polyclonal unconjugated

Anti- Cyclin D1 antibody, All Western blottingAll lanes: Anti-CCND1 at 0.

1 image

(40 references)

产品编号 ABIN5518654

发货至: 中国

Datasheet as PDF

抗原 See all Cyclin D1 (CCND1) 抗体

Cyclin D1 (CCND1)
抗原表位
22

21

16

16

13

11

9

9

7

7

7

7

7

6

6

5

3

3

3

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 19-37, N-Term
适用
241

128

123

38

19

19

17

10

9

8

4

3

3

3

3

2

1

1

1

1

1
人, 大鼠
宿主
209

56

1
兔
Compatible Secondaries
克隆类型
198

66
多克隆
标记
117

29

21

9

8

7

7

7

7

7

7

5

3

3

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1
This Cyclin D1 antibody is un-conjugated
应用范围
202

89

70

66

42

31

27

27

25

22

19

13

6

5

3

2

2

2

1

1
Western Blotting (WB)

原理

Rabbit IgG polyclonal antibody for G1/S-specific cyclin-D1(CCND1) detection. Tested with WB in Human,Rat.

序列

DANLLNDRVL RAMLKAEET

交叉反应（详细）

No cross reactivity with other proteins.

产品特性

Rabbit IgG polyclonal antibody for G1/S-specific cyclin-D1(CCND1) detection. Tested with WB in Human,Rat.
Gene Name: cyclin D1
Protein Name: G1/S-specific cyclin-D1

纯化方法

Immunogen affinity purified.

免疫原

A synthetic peptide corresponding to a sequence at the N-terminus of human Cyclin D1(19-37aa DANLLNDRVLRAMLKAEET), different from the related mouse and rat sequences by two amino acids.

亚型

IgG

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CCND1 适用: 人, 大鼠, 小鼠, 猴 WB, IHC, FACS, IF, StM 宿主: 小鼠 Monoclonal DCS-6 unconjugated

应用备注

WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat, The detection limit for CCND1 is approximately 2.5 ng/lane under reducing conditions.
Notes: Tested Species: Species with positive results.
Other applications have not been tested. Optimal dilutions should be determined by end users.

说明

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

限制

仅限研究用
状态

Lyophilized

溶解方式

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

浓度

500 μg/mL

缓冲液

Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

储存液

Sodium azide, Thimerosal (Merthiolate)

注意事项

This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
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抗原

Cyclin D1 (CCND1)

别名

CCND1 (CCND1 产品)

别名

BCL1 antibody, D11S287E antibody, PRAD1 antibody, U21B31 antibody, AI327039 antibody, CycD1 antibody, Cyl-1 antibody, bcl-1 antibody, cD1 antibody, cb161 antibody, cycd1 antibody, etID37810.7 antibody, fb52e01 antibody, fc45c08 antibody, fc83a12 antibody, id:ibd1198 antibody, wu:fb52e01 antibody, wu:fc45c08 antibody, wu:fc83a12 antibody, ccnd1b antibody, prad1 antibody, ccnd1 antibody, ccnd1a antibody, bcl1 antibody, d11s287e antibody, u21b31 antibody, CCND1 antibody, cyclin D1 antibody, cyclin D1 S homeolog antibody, cyclin D1 L homeolog antibody, CCND1 antibody, Ccnd1 antibody, ccnd1 antibody, ccnd1.S antibody, ccnd1.L antibody

背景

Cyclin D1, also known as CCND1, is a human gene. The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclin D1 encodes the regulatory subunit of a holoenzyme that phosphorylates and inactivates the retinoblastoma protein and promotes progression through the G1-S phase of the cell cycle. Amplification or overexpression of cyclin D1 plays pivotal roles in the development of a subset of human cancers including parathyroid adenoma, breast cancer, colon cancer, lymphoma, melanoma, and prostate cancer. The cyclin D1 gene is overexpressed in human breast cancers and is required for oncogene-induced tumorigenesis. Brisken et al. (2003) found that prolactin (PRL, 176760) induced IGF2 (147470) mRNA and IGF2 induced cyclin D1 protein expression in mouse mammary epithelial cultures. And they also concluded that IGF2 is a mediator of prolactin-induced alveologenesis and that prolactin, IGF2, and cyclin D1 are components of a developmental pathway in mammary gland.

Synonyms: AI327039 antibody|B cell ccl/lymphoma 1 antibody|B cell CLL/lymphoma 1 antibody|B cell leukemia 1 antibody|B-cell leukemia 1 antibody|B cell lymphoma 1 protein antibody|B-cell lymphoma 1 protein antibody|BCL 1 antibody|BCL-1 antibody|BCL-1 oncogene antibody|BCL1 antibody|BCL1 oncogene antibody|CCND 1 antibody|CCND1 antibody|CCND1 protein antibody|CCND1/FSTL3 fusion gene, included antibody|CCND1/IGHG1 fusion gene antibody|CCND1/IGHG1 fusion gene, included antibody|CCND1/IGLC1 fusion gene, included antibody|CCND1/PTH fusion gene, included antibody|CCND1_HUMAN antibody|cD1 antibody|Cyl 1 antibody|D11S287E antibody|G1/S specific cyclin D1 antibody|G1/S-specific cyclin-D1 antibody|Parathyroid adenomatosis 1 antibody|PRAD1 antibody|PRAD1 oncogene antibody|U21B31 antibody

基因ID

595

UniProt

P24385

途径

PI3K-Akt Signaling, Cell Division Cycle, Mitotic G1-G1/S Phases, ER-Nucleus Signaling