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APOE 抗体 (N-Term)

There are 3+ publications for this product available. The 兔多克隆 anti-APOE antibody is suitable to detect APOE in samples from 人. It has been validated for WB 和 IHC.

IHC

2 images

(3 references)

产品编号 ABIN503507

发货至: 中国

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Quick Overview for APOE 抗体 (N-Term) (ABIN503507)

抗原

See all APOE 抗体

APOE (Apolipoprotein E (APOE))

适用

人

宿主

兔

克隆类型

多克隆

标记

This APOE antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (IHC)

Discover our top product APOE Primary Antibody

抗原表位
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1
N-Term

序列

KVLWAALLVT FLAGCQAKVE QAVETEPEPE LRQQTEWQSG QRWELALGRF

预测反应

Human: 100%

产品特性

This is a rabbit polyclonal antibody against APOE. It was validated on Western Blot using a cell lysate as a positive control.

纯化方法

Affinity Purified

免疫原

The immunogen is a synthetic peptide directed towards the N terminal region of human APOE
anti-Apolipoprotein E (APOE) (AA 1-172) antibody
APOE 适用: 犬 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Apolipoprotein E (APOE) (AA 19-168) antibody
APOE 适用: 大鼠 WB, IHC, IP, ICC, FACS 宿主: 兔 Polyclonal unconjugated

anti-Apolipoprotein E (APOE) (AA 19-168) antibody
APOE 适用: 大鼠 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C5 unconjugated

anti-Apolipoprotein E (APOE) (AA 19-181) antibody
APOE 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Apolipoprotein E (APOE) (C-Term) antibody
APOE 适用: 人 WB, ELISA, IP, ICC, IF, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Apolipoprotein E (APOE) (AA 200-300) antibody
APOE 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Apolipoprotein E (APOE) antibody
APOE 适用: 人 IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 1H4 unconjugated

anti-Apolipoprotein E (APOE) (AA 55-294) antibody
APOE 适用: 小鼠, 大鼠 WB, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated

anti-Apolipoprotein E (APOE) (N-Term) antibody
APOE 适用: 人 WB, ICC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Apolipoprotein E (APOE) (AA 151-250) antibody
APOE 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated

应用备注

Optimal working dilutions should be determined experimentally by the investigator.

说明

Antigen size: 317 AA

限制

仅限研究用
状态

Liquid

浓度

Lot specific

缓冲液

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freeze-thaw cycles.

储存条件

-20 °C

储存方法

For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Day, McCarty, Ockerse, Head, Rohn: "Proteolytic Cleavage of Apolipoprotein E in the Down Syndrome Brain." in: Aging and disease, Vol. 7, Issue 3, pp. 267-77, (2016) (PubMed).

Rohn, Day, Sheffield, Rajic, Poon: "Apolipoprotein E pathology in vascular dementia." in: International journal of clinical and experimental pathology, Vol. 7, Issue 3, pp. 938-47, (2014) (PubMed).

Rohn, Catlin, Coonse, Habig: "Identification of an amino-terminal fragment of apolipoprotein E4 that localizes to neurofibrillary tangles of the Alzheimer's disease brain." in: Brain research, Vol. 1475, pp. 106-15, (2012) (PubMed).
抗原

APOE (Apolipoprotein E (APOE))

别名

APOE

背景

Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: AD2, MGC1571, apoprotein, LPG, LDLCQ5
Protein Interaction Partner: LCAT, ARFGAP1, ALB, C19orf52, LOXL4, PRAM1, MID1IP1, ANKH, FBXL12, FXYD7, ECSIT, PDCD4, IFIT5, MAST1, EPN2, PLEKHA6, CDC37, IQSEC1, LONP1, TYRO3, PRDX2, ST13, RPL4, RHEB, PSEN1, HTRA1, PCMT1, ZNF558, NOS3, IFIT3, GCDH, FOXG1, FARSA, ELAVL1, CYP2C18, CYP2C
Protein Size: 317

分子量

34 kDa

基因ID

348

NCBI登录号

NM_000041, NP_000032

UniProt

P02649

途径

Regulation of Cell Size, Lipid Metabolism